货号：MAB5412

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Indoleamine 2,3-dioxygenase Antibody, clone 10.1 | MAB5412 View All» Replaces: AB5968 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with Indolamine 2,3-dioxygenase (IDO). Note IDO is usually expressed in response to various stimuli. A good positive control is HeLa cells stimulated with IFN-gamma, {http://www.upstate.com/browse/productdetail.q.ProductID.e.05-840#}. View All» Molecular Weight: 42-45kDa View All» Immunogen: Amino acids 78-184 of human IDO fused to GST. View All» Clone: 10.1 View All» Isotype: IgG3 View All» Background Information: Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Expected to react with mouse and rat based on sequence homology. View All» Application Notes: Immunohistochemistry: A previous lot of this antibody worked on lightly fixed tissues; Triton X-100 treatment only in the block, not with primary antibody. High temperature antigen retrieval is recommended.Western blot: Recognizes a 42-45kDa band in IFN-gamma treated human HeLa cell lines. Mouse IDO runs slightly smaller in blots than human IDO. Optimal working dilutions must be determined by end user. View All» Control: IFN-gamma stimulated human peripheral blood lymphocytes, HeLa lysates. View All» Quality Assurance: Routinely evaluated by Western Blot on untreated and IFNgamma treated HeLa lysates.Western blot: 1:500 dilution of this lot detected IDO on 10 μg of untreated and IFN gamma treated HeLa lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG3 in buffer containing 0.02 M phosphate, 0.25 M NaCl, 0.1% NaN3, pH 7.6. View All» Storage Conditions: Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt. View All» UniProt Number: P14902 View All» Entrez Gene Number: NM_002164.4 View All» Gene Symbol:
  • IDO

  • INDO

  • EC 1.13.11.52
    View All» Alternate Names: Indoleamine-pyrrole 2,3-dioxygenase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Gamma-interferon (IFNG; MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.42). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P14902 # Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.COFACTOR: Binds 1 heme group per subunit.SIZE: 403 amino acids; 45326 Da SIMILARITY: SwissProt: P14902 ## Belongs to the indoleamine 2,3-dioxygenase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Indoleamine 2,3-dioxygenase Antibody, clone 10.1 | MAB5412 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MAB5412 Anti-Indoleamine 2,3-dioxygenase Antibody, clone 10.1;抗-吲哚胺2,3-双加氧酶抗体，克隆10.1store at +2℃ to +8℃，产品报价联系微信jinshanbio