货号：04-742

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SHP-1/2 Antibody, clone NL213 | 04-742 View All» Replaces: 05-742 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes SHP-1 greater than SHP-2, Mr ~65 kDa View All» Molecular Weight: ~65kDa View All» Immunogen: Full-length glutathione transferase SHP-1 fusion protein, purified from bacteria View All» Clone: NL213 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. Others not tested. View All» Quality Assurance: routinely evaluated by immunoblot in RIPA lysates from human A431 carcinoma cells View All» Presentation: Cultured supernantant in 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P29350 View All» Entrez Gene Number: NM_002831, NM_002834 View All» Gene Symbol:
  • PTPN6

  • HCP

  • SH-PTP1

  • PTP-1C

  • SHP1

  • SHP-1L

  • PTP1C

  • HCPH

  • SHP-1

  • HPTP1C
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P29350 # Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.SIZE: 595 amino acids; 67561 Da SUBUNIT: Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LILRB2. Interacts with FCRL2, CD300LF and CD84.SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity).TISSUE SPECIFICITY: Isoform 1 is expressed in hematopoietic cells while isoform 2 is expressed in non-hematopoietic cells.PTM: Phosphorylated on serine and tyrosine residues.SIMILARITY: SwissProt: P29350 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. & Contains 2 SH2 domains. & Contains 1 tyrosine-protein phosphatase domain. View All» Brand Family: Upstate View All» Product Name: Anti-SHP-1/2, clone NL213 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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