货号：04-721

品牌：Merck Millipore

规格：1EA

目录价：￥4570.85

市场价格：￥3885.22

会员价格：￥3656.68

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dicer1 Antibody, clone 5D12.2 | 04-721 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Human Dicer1 View All» Molecular Weight: 220 kDa View All» Immunogen: KLH conjugated synthetic peptide corresponding to amino acids 378-385 of human Dicer1 View All» Clone: 5D12.2 View All» Isotype: IgG1κ View All» Background Information: RNA interference (RNAi) is mechanism for post-transcriptional gene silencing that leads to the loss of the activity of the gene. RNAi is activated when long dsRNAs are cleaved by the enzyme Dicer1 (RNase III family of dsRNA-specific endonucleases) into 21-23 nucleotide siRNA (small interfering RNA). These siRNAs bind proteins to form the RISC (RNA-induced silencing complex) which is activated when the double stranded siRNAs are unzipped to single stranded siRNAs. Activated RISC recognizes and binds complementary sequences in mRNA. The mRNA is cleaved and the overall effect is an inhibition of the protein expression and a loss of the gene activity. Dicer1 along with the Argonaute family of proteins (Ago1 and Ago2) share the same domain PIWI and PAZ domain that provide endonuclease activity to RNA-induced silencing complexes (RISC). View All» Species Reactivity: Human View All» Application Notes: Western blot View All» Quality Assurance: Routinely evaluated by western blot on lysates from HeLa nuclear extracts. View All» Purification Method: Protein G chromatography View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q9UPY3 View All» Entrez Gene Number: NP_085124.2 View All» Gene Symbol:

• DICER1

• DICER

• HERNA
  View All» Alternate Names:
  • DCR1

  • Dicer

  • HERNA

  • KIAA0928
    View All» Key Applications: Western Blotting View All» Brand Family: Upstate View All» Product Name: Anti-Dicer1, clone 5D12.2 Antibody View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Purified View All» Host: Mouse View All»
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