货号：04-640

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LAP2α Antibody, clone 3A3 | 04-640 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Human LAP2α. Does not cross react with mouse or rat LAP2α View All» Molecular Weight: 76 kDa View All» Immunogen: KLH conjugated synthetic peptide to C terminus region of human LAPα. This antibody detects LAP2α regardless of a naturally occurring Arginine to Cysteine mutation at position 690. View All» Clone: clone 3A3 View All» Isotype: IgG1κ View All» Background Information: The inner membrane of the nuclear envelope is connected to the nuclear lamina. The main components of the nuclear lamina are Type V intermediate filaments called lamins and lamin binding proteins including lamin B receptor, emerin, MANI, LAP1 (3 isoforms), and LAP2 (several isoforms). The lamins are divided into two groups: the constitutively expressed lamin B and the developmentaly regulated lamin A. The best characterized isoforms of lamin binding protein LAP2 are LAP2α and LAP2β. LAP2β is a type II membrane protein in the inner nuclear membrane that binds lamin B and is important to cell viability and controlling nuclear lamina growth. LAP2α has been characterized as a nucleoplasmic protein that interacts with A-type lamins to control gene expression, transcription, and chromatin organization. LAP2 has a unique COOH terminus from the other LAP2 isoforms. The COOH terminus of LAP2 binds Rb (Retinoblastoma) and is thought to play a role in cell cycle progression and differentiation. View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on lysates from K563 cells View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% NaN3. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: P42166 View All» Entrez Gene Number: NM_003276 View All» Gene Symbol: TMPO View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Western Blotting

• Immunofluorescence
  View All» Brand Family: Upstate View All» Product Name: Anti-LAP2α, clone 3A3 Antibody (04-640) View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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