货号：04-589

品牌：Merck Millipore

规格：

目录价：￥3732.00

市场价格：￥3172.20

会员价格：￥2985.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calponin-1 (C-Term) Antibody, Rabbit, clone EP798Y | 04-589 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human, Mouse, Rat Calponin-1 (C-Term). View All» Immunogen: A synthetic peptide corresponding to residues near the C-term of human Calponin. View All» Clone: EP798Y View All» Background Information: Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein thought to be involved in regulation of actomyosin as well as the regulation or modulation of contraction (1). Calponin binds filamentous actin (F-actin) through two distinct sites ABS1 and ABS2, with an affinity in the low micromolar range (2) Immunoreactivity for calponin, along with alpha-smooth muscle actin and smooth muscle myosin heavy chains, confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistently positive staining pattern in adenoid cystic carcinomas may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas (3). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Mouse, Rat (positive control: human bladder lysate) View All» Application Notes: WB: 1:20,000 IHC: 1:100 - 250 (Paraffin-embedded human smooth muscle) ICC: 1:100 - 250 (Hela cells) View All» Purification Method: Protein A purfied View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: P51911 View All» Entrez Gene Number: NM_001299.4 View All» Gene Symbol:
  • CNN1

  • SMCC

  • Sm-Calp

  • Calponin-1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» UniProt Summary: FUNCTION: SwissProt: P51911 # Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).SIZE: 297 amino acids; 33170 Da SUBUNIT: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity).TISSUE SPECIFICITY: Smooth muscle, and tissues containing significant amounts of smooth muscle.SIMILARITY: SwissProt: P51911 ## Belongs to the calponin family. & Contains 3 calponin-like repeats. & Contains 1 CH (calponin-homology) domain. View All» Brand Family: Upstate View All» Product Name: Anti-Calponin-1 (C-Term) Antibody, Rabbit, clone EP798Y | 04-589 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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