货号：04-572

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Caspase-6 (C-Term) Antibody | 04-572 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human, Mouse Caspase-6 (C-Term). View All» Immunogen: A synthetic peptide corresponding to residues in C-terminus of human Caspase-6. The antibody should recognize both pro-form and p11 subunit. View All» Clone: E180 View All» Background Information: Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4). View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse (positive control: Jurkat cell lysate) View All» Application Notes: WB: 1:1,000 IHC: 1:50 (Paraffin-embedded human lung adenocarcinoma) ICC: 1:100 (Hela cells) Flow Cytometry: 1:30 View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: P55212 View All» Entrez Gene Number:
  • NM_001226.3

  • NM_032992.2
    View All» Gene Symbol:
    • CASP6

    • CASP-6

    • MCH2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P55212 # Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.SIZE: 293 amino acids; 33310 Da SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.SUBCELLULAR LOCATION: Cytoplasm.PTM: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.SIMILARITY: SwissProt: P55212 ## Belongs to the peptidase C14 family. View All» Brand Family: Upstate View All» Product Name: Anti-Caspase-6 (C-Term) Antibody | 04-572 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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