货号：MAB5264

品牌：Merck Millipore

规格：50Ug

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 | MAB5264 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with NGF-receptors in human system. View All» Molecular Weight: 75 kDa View All» Immunogen: Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983). View All» Clone: 8211 View All» Isotype: IgG1 View All» Background Information: The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: 5-10 μg/mL Immunocytochemistry: 5-10 μg/mL Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf Western Blot: 1ug/mL Immunoabsorptive purification of NGF-receptors Optimal working dilutions must be determined by end user. View All» Control: Brain tissue View All» Purification Method: Protein A purfied View All» Presentation: Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P08138 View All» Entrez Gene Number: NM_002507.2 View All» Gene Symbol:

• NTF3

• NT3

• NGF2

• HDNF

• MGC129711

• NGF-2

• NT-3
  View All» Alternate Names: NGF-Receptor p75; Low Affinity NGF Receptor; NGFR View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunocytochemistry

  • Immunohistochemistry

  • Immunohistochemistry (Paraffin)

  • Western Blotting
    View All» Entrez Gene Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. View All» UniProt Summary: FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.SIZE: 427 amino acids; 45183 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 | MAB5264 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 μg View All» Target / Localization: Plasma membrane View All» Format: Purified View All» Host: Mouse View All»
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