货号：04-400

品牌：Merck Millipore

规格：

目录价：￥3510.00

市场价格：￥2983.50

会员价格：￥2808.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PI3 Kinase Antibody, p110β, Rabbit | 04-400 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes a region in the N-terminus domain of human PI3 Kinase, p110β. Non specific band detected at MW 55 kDa. View All» Molecular Weight: 110 kDa View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated synthetic peptide corresponding to the N-terminal region of human PI3 Kinase, p110β View All» Clone: Y384 View All» Isotype: IgG View All» Background Information: PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Reactivity with other species has not been confirmed. View All» Application Notes: Immunoprecipitation: A 1:50 dilution of a previous lot of this antibody immunoprecipitated PI3 Kinase, p110β using protein G:agarose beads.Flow Cytometry: A 1:40 of a previous lot of this antibody stained cells for intracellular staining for flow Cytometry analysis. View All» Control: Jurkat cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on jurkat cell lysate.Western Blot Analysis: A 1:500 dilution of this lot detected endogenous PI3 Kinase, p110β in lysate from Jurkat cells. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit monoclonal IgG in buffer containing 0.03% BSA, 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide as a preservative in a solution of 40% glycerol View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage View All» UniProt Number: P42338 View All» Entrez Gene Number: NM_006219.1 View All» Gene Symbol: PIK3CB PI3Kbeta MGC133043 PIK3C1 DKFZp779K1237 View All» Alternate Names:

• PI3-kinase p110 subunit beta

• PtdIns-3-kinase p110

• phosphatidylinositol 3-kinase, catalytic, beta polypeptide

• phosphoinositide-3-kinase, catalytic, beta polypeptide
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P42338 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.SIZE: 1070 amino acids; 122762 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit.TISSUE SPECIFICITY: Expressed ubiquitously.SIMILARITY: SwissProt: P42338 ## Belongs to the PI3/PI4-kinase family. & Contains 1 PI3K/PI4K domain. View All» Brand Family: Upstate View All» Product Name: Anti-PI3 Kinase Antibody, p110β, Rabbit | 04-400 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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