货号：MAB4444

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8 | MAB4444 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes epithelial cell adhesion molecule (EpCAM), specifically on undifferentiated human embryonic stem cells. View All» Molecular Weight: ~ 40 kDa View All» Epitope: Unknown View All» Immunogen: HES-3 Cells (Choo, et al. (2008) Stem Cells. Jun;26(6):1454-63) View All» Clone: mab 8 View All» Isotype: IgG2aκ View All» Background Information: Epithelial Call Adhesion Molecule (EpCAM, CD326) is a transmembrane glycoprotein of approximately 40 kDa. EpCAM was initially identified as a tumor associated marker having high expression in quickly proliferating epithelial tumors. As such, EpCAM has been of significant interest as a means for tumor diagnosis and therapy. EpCAM is also expressed in normal epithelial cells, but in comparatively lower levels. Preliminary studies limited EpCAM’s function to cell-cell adhesion; however more recent studies indicate it to be involved in diverse processes that include cell migration, cell signaling, differentiation and proliferation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Flow Cytometry Analysis: 0.5 µg from a previous lot detected Epithelial cell adhesion molecule in human embryonic stem cells.Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Ng, V., et al., 2010) View All» Control: Human embryonic stem cells View All» Quality Assurance: Evaluated by Immunocytochemistry in human embryonic stem cells.Immunocytochemistry Analysis: 1-10 µg/mL from a previous lot detected epithelial cell adhesion molecule (EpCAM) in human embryonic stem cells. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P16422 View All» Entrez Gene Number: NP_002345.2 View All» Gene Symbol:

• EPCAM

• 17-1A

• 323/A3

• CD326

• CO-17A

• CO17-1A

• EGP

• EGP-2

• EGP34

• EGP40

• ESA

• Ep-CAM

• GA733-2

• HEA125

• KS1/4

• KSA

• Ly74

• M1S2

• M4S1

• MH99

• MIC18

• MK-1

• MOC31

• TACST-1

• TACSTD1

• TROP1

• hEGP-2
  View All» Alternate Names:
  • Adenocarcinoma-associated antigen

  • CD326 antigen

  • Cell surface glycoprotein Trop-1

  • Epithelial cell surface antigen

  • Epithelial glycoprotein

  • KS 1/4 antigen

  • Major gastrointestinal tumor-associated protein GA733-2

  • antigen identified by monoclonal antibody AUA1

  • carcinoma-associated antigen GA733-2

  • epithelial cell adhesion molecule

  • human epithelial glycoprotein-2

  • membrane component, chromosome 4, surface marker (35kD glycoprotein)

  • tumor-associated calcium signal transducer 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection.SUBUNIT STRUCTURE: Monomer. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas.SEQUENCE SIMILARITIES: Belongs to the EPCAM family.Contains 1 thyroglobulin type-1 domain. View All» Product Name: Anti-Epithelial Cell Adhesion Molecule (EpCAM), clone mAb 8 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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