货号：04-381

品牌：Merck Millipore

规格：

目录价：￥3662.00

市场价格：￥3112.70

会员价格：￥2929.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MKK3 NT Antibody | 04-381 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes MKK3 View All» Molecular Weight: 40 kDa View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated synthetic peptide corresponding to residues in the N-term of human MKK3. View All» Isotype: IgG View All» Species Reactivity: Human View All» Application Notes: Western Blot: 1,5,000-1:20,000. Immunoprecipitation: 1:50. The use of protein G agarose is recommended. Flow Cytometry: 1:50. Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE: Jurkat, HeLa, MCF-7 or K562 cells. View All» Quality Assurance: Routinely evaluated by immunoblot analysis. View All» Purification Method: Protein G purfied View All» Presentation: Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol. View All» Storage Conditions: 2 years at -20°C from date of shipment. View All» UniProt Number: P46734 View All» Entrez Gene Number:

• NM_145110.1

• NM_002756.3

• NM_145109.2
  View All» Gene Symbol:
  • MAP2K3

  • MAPKK3

  • PRKMK3

  • MEK3

  • MKK3
    View All» Alternate Names: MAPKK3, MEK3, PRKMK3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P46734 # Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.SIZE: 347 amino acids; 39318 Da SUBUNIT: Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with Yersinia yopJ.TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.PTM: Autophosphorylated. & Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. & Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.DISEASE:SwissProt: P46734 # Defects in MAP2K3 may be involved in colon cancer.SIMILARITY: SwissProt: P46734 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-MKK3 NT Antibody | 04-381 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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