货号：MAB4430

品牌：Merck Millipore

规格：

目录价：￥4025.00

市场价格：￥3421.25

会员价格：￥3220.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Piwi-like protein 2 Antibody, clone 87/3 | MAB4430 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Piwi-like protein 2 at the N-terminus. View All» Molecular Weight: 110 kDa calculated View All» Epitope: N-terminus View All» Immunogen: Linear peptide corresponding to human Piwi-like protein 2 at the N-terminus. View All» Clone: 87/3 View All» Isotype: IgM View All» Background Information: Piwi-like protein 2 (PIWIL2) is a member of the Argonaute family of proteins and play essential roles in stem-cell self-renewal, RNA silencing and translational regulation in various organisms. Piwi-like protein 2 is not present in normal cells (other than testicular), or in inflammatory tissues; however, it is present in almost all cancer cell types. Piwi-like protein 2 inhibits tumor cell growth when repressed and acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Other homologies: Mouse (73% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:300 dilution of this antibody has been shown to detect Piwi-like protein 2 in prostatic adenocarcinoma and human testis tissue. View All» Control: Colorectal adenocarcinoma tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected Piwi-like protein 2 in colorectal adenocarcinoma tissue. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgM containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8TC59 View All» Entrez Gene Number: NP_001129193 View All» Gene Symbol:

• HILI

• PIWIL1L

• CT80

• Mili

• MILI

• mili

• PIWIL2
  View All» Alternate Names:
  • piwi-like 2 (Drosophila)

  • piwi-like 2

  • Hiwi-like

  • Miwi like

  • Cancer/testis antigen 80

  • Mili

  • MILI

  • mili
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate to similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (By similarity).SUBUNIT STRUCTURE: Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes. Interacts (when methylated on arginine residues) with TDRD1 (By similarity).SUBCELLULAR LOCATION: Cytoplasm By similarity. Note: Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis (By similarity).TISSUE SPECIFICITY: Expressed in adult testis and in most tumors. PTM: Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule (By similarity).SEQUENCE SIMILARITIES: Belongs to the argonaute family. Piwi subfamily.Contains 1 PAZ domain.Contains 1 Piwi domain.SEQUENCE CAUTION: The sequence BAA91558.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB55155.1 differs from that shown. Reason: Erroneous termination at position 421. Translated as Arg. View All» Product Name: Anti-Piwi-like protein 2, clone 87/3 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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