货号：MAB4429

品牌：Merck Millipore

规格：

目录价：￥4025.00

市场价格：￥3421.25

会员价格：￥3220.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BMP-7 (Pro-peptide) Antibody, clone 2 | MAB4429 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the pro-peptide form of BMP-7. View All» Molecular Weight: The molecular band seen is the pro-peptide form of BMP-7, ~31 kDa (Gregory, K.E., et al., 2005). View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to human BMP-7 (Pro-peptide). View All» Clone: mab 2 View All» Isotype: IgG1κ View All» Background Information: Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Gregory, K.E., et al., 2005).Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC (Gregory, K.E., et al., 2005).Immunohistochemistry (paraffin) Analysis: A 1:200 dilution of a previous lot was used to detect BMP-7 (pro-peptide) in human kidney tissue. A previous lot was used by an independent laboratory in IH (Gregory, K.E., et al., 2005). View All» Control: Human kidney tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human kidney tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected BMP-7 (Pro-peptide) in 10 µg of human kidney tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P18075 View All» Entrez Gene Number: NP_001710 View All» Gene Symbol:

• BMP7

• BMP-7

• OP1

• OP-1
  View All» Alternate Names:
  • bone morphogenetic protein 7

  • Osteogenic protein 1

  • Eptotermin alfa
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)

    • ELISA

    • Immunocytochemistry
      View All» Entrez Gene Summary: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in the kidneys and bladder. Lower levels seen in the brain.PTM: Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).PHARMACEUTICAL USE: Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.SEQUENCE SIMILARITIES: Belongs to the TGF-beta family. View All» Product Name: Anti-BMP-7 (Pro-peptide), clone mab 2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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