货号：MAB4425

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDX-1 Antibody, clone 6F6.1 | MAB4425 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: 0 View All» Molecular Weight: ~31 kDa observed View All» Epitope: 0 View All» Immunogen: GST-tagged recombinant protein corresponding to human PDX-1. View All» Clone: 6F6.1 View All» Isotype: IgG2bκ View All» Background Information: Pancreas/duodenum homeobox protein 1 (PDX-1) belongs to the homeodomain-containing transcription factor family. PDX-1 is a critical factor in the processes of development and differentiation of the pancreas, specifically through the designation of early pancreatic epithelium, allowing it to proliferate, branch and ultimately differentiate. It has been shown to stimulate gene transcription for insulin, islet amyloid polypeptide, glucokinase, glucose transporter type 2, and somatostatin. PDX-1 also serves to regulate beta cells past development and into the adult stage. Defects in PDX-1 are the cause of several pancreatic diseases including; pancreatic agenesis, maturity-onset diabetes of the young type 4, and non-insulin-dependent diabetes mellitus. Up-regulation of PDX-1 in adult tissue has been associated with pancreatitis and pancreatic cancer. PDX-1 is expressed in the duodenum and pancreas tissues. It is also found in pancreatic progenitor cells. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A 1:400 dilution from a previous lot detected PDX-1 in islet of langerhans of normal pancreas tissue. View All» Control: Panc-1 cell lysate View All» Quality Assurance: Evaluated by Western Blot in Panc-1 cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected PDX-1 in 10 µg of Panc-1 cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P52945 View All» Entrez Gene Number: NP_000200 View All» Gene Symbol:

• PDX1

• IPF1

• IDX-1

• GSF

• IUF1

• IPF-1

• STF-1

• MODY4

• PDX-1

• IUF-1
  View All» Alternate Names:
  • Pancreas Duodenum Homeobox-1

  • insulin promoter factor 1, homeodomain transcription factor

  • pancreatic-duodenal homeobox factor 1

  • pancreas/duodenum homeobox protein 1

  • Insulin upstream factor 1

  • Glucose-sensitive factor

  • somatostatin transcription factor 1

  • Somatostatin-transactivating factor 1

  • Insulin promoter factor 1

  • Islet/duodenum homeobox-1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.SIZE: 283 amino acids; 30771 Da SUBUNIT: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP (By similarity).SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).DOMAIN: The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By similarity). & The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein- protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By similarity).PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.DISEASE: Defects in PDX1 are a cause of pancreatic agenesis [MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant. & Defects in PDX1 are the cause of maturity onset diabetes noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type II. & Defects in PDX1 are the cause of maturity onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.SIMILARITY: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. & Contains 1 homeobox DNA-binding domain. ... View All» Product Name: Anti-PDX-1, clone 6F6.1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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