货号：MAB4423A4

品牌：Merck Millipore

规格：

目录价：￥4934.00

市场价格：￥4193.90

会员价格：￥3947.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SOX-2 Antibody, clone 10H9.1, Alexa Fluor® 488 conjugate | MAB4423A4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 34 kDa calculated View All» Immunogen: recombinant protein corresponding to human SOX-2. View All» Isotype: IgG2bκ View All» Background Information: SOX-2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS. SOX-2 has been identified as a key transcription factor required for cellular reprogramming. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. View All» Application Notes: Evaluated by Immunocytochemistry in H9 Human Embryonic Stem Cells. Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected SOX-2 in H9 Human Embryonic Stem Cells. View All» Control: Mouse Embryonic Stem Cells (SCR012). View All» Quality Assurance: Evaluated by Immunocytochemistry in Mouse Embryonic Stem Cells (SCR012). Immunocytochemsitry Analysis: A 1:100 dilution of this antibody detected SOX-2 in Mouse Embryonic Stem Cells (SCR012). View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2b conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15mg/ml BSA. View All» Storage Conditions: Maintain refrigerated at 2-8ºC protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P48431 View All» Entrez Gene Number: NP_003097 View All» Gene Symbol: SOX2 View All» Alternate Names:
  • SOX2

  • ANOP3

  • MCOPS3

  • MGC2413

  • SRY related HMG BOX gene 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» Product Name: Anti-SOX-2, clone 10H9.1, Alexa Fluor® 488 conjugate View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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