货号：MAB4423

品牌：Merck Millipore

规格：100Ug

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SOX-2 Antibody, clone 10H9.1 | MAB4423 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~34 kDa observed View All» Immunogen: Recombinant protein corresponding to human SOX-2. View All» Clone: 10H9.1 View All» Isotype: IgG2bκ View All» Background Information: SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX1, SOX2 and SOX3 show the closest homology to SRY. They share maximum homology within the HMG domain and are expressed mainly in the developing nervous system of the mouse. These genes share significant homology outside the HMG box also and are highly conserved throughout their evolution. Sox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Human. View All» Application Notes: Western Blot Analysis: 1.0 µg/mL from a representative lot detected SOX-2 in H9 human stem cell lysate.Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected SOX-2 in human RenCX cells. View All» Control: Mouse embryonic stem cells View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected SOX-2 in mouse embryonic stem cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P48431 View All» Entrez Gene Number: NP_003097 View All» Gene Symbol: SOX2 View All» Alternate Names:
  • ANOP3

  • MCOPS3

  • MGC2413
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). View All» UniProt Summary: FUNCTION: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 By similarity. Critical for early embryogenesis and for embryonic stem cell pluripotency.SUBUNIT STRUCTURE: Interacts with ZSCAN10.SUBCELLULAR LOCATON: Nucleus. View All» Product Name: Anti-SOX-2, clone 10H9.1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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