货号：MAB4419

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2 | MAB4419 View All» Replaces: MAB4305 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody reacts with the intracellular protein, Oct-4 and detects the Oct-4A isoform. View All» Molecular Weight: ~39 kDa View All» Immunogen: Recombinant human Oct-4 protein, a.a. 1-145. View All» Clone: 7F9.2 View All» Isotype: IgG1κ View All» Background Information: Octamer-4 (Oct-4), a member of the POU family of transcription factors, has been demonstrated to be vital for the formation of self-renewing pluripotent stem cells. During embryogenesis, expression of Oct-4 is limited to pluripotent cells of the inner cell mass (ICM) that contribute to the formation of all fetal cell types. This relationship between Oct-4 and pluripotency has seen this transcription factor emerge as a marker of pluripotent stem cells. Undifferentiated human and murine pluripotent Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells express Oct-4. Additionally, murine Embryonic Germ (EG) cells are also known to express Oct-4. Following stem cell differentiation, the level of Oct-4 expression decreases. Oct-4 expression by human EG cells is not known. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Reacts with both human and mouse Oct-4; however, reactivity to other species has not been determined. View All» Application Notes: Western Blotting: Recommended working dilution is 1 - 2 µg/mL.Flow Cytometry: Recommended working dilution is 2 µg/mL.Immunocytochemistry: Recommended working dilution is 1:100 – 1: 200. View All» Purification Method: Protein G sepharose column View All» Presentation: Purified mouse monoclonal IgG1κ in a buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% NaN3. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P20263 View All» Entrez Gene Number: NP_976034 View All» Gene Symbol:
  • OCT3

  • OCT4

  • OTF3

  • OTF4

  • Oct-3

  • Oct-4
    View All» Alternate Names:
    • Octamer-binding transcription factor 3

    • POU class 5 homeobox 1

    • POU domain class 5, transcription factor 1

    • POU-type homeodomain-containing DNA-binding protein

    • octamer-binding transcription factor-3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Flow Cytometry

      • Western Blotting
        View All» UniProt Summary: FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. SUBUNIT STRUCTURE:Interacts with UBE2I. SUBCELLULAR LOCATION: Nucleus. Note= Expressed in a diffuse and slightly punctuate pattern. TISSUE SPECIFICTY: Expressed the totipotent and pluripotent stem cells of the pregastrulation embryo. Also expressed in primordial germ cells and in the female germ line. Absent from adult tissues. DEVELOPMENTAL STAGE: Down-regulated during differentiation to endoderm and mesoderm. Ref.1INDUCTION: Repressed by retinoic acid (RA). PTM: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression.SEQUENCE SIMILARITIES: Belongs to the POU transcription factor family. Class-5 subfamily.Contains 1 homeobox DNA-binding domain.Contains 1 POU-specific domain. View All» Product Name: Anti-OCT-4 [POU5F1] Antibody, clone 7F9.2 | MAB4419 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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