货号：04-360

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GSK3 alpha Antibody, clone EP793Y, Rabbit Monoclonal | 04-360 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of GSK3 alpha. View All» Molecular Weight: ~83 kDa observed View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to the N-terminus of human GSK3 alpha. View All» Clone: EP793Y View All» Isotype: IgG View All» Background Information: Glycogen synthases kinase 3 alpha (GSK3-Alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-Alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-Alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-Alpha activity has been linked to a pathogenic mechanism in Alzheimer's disease (4). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunohistochemistry Analysis: A 1:50-100 dilution from a representative lot was used in breast carcinoma tissue.Immunocytochemistry Analysis: A 1:50-100 dilution from a representative lot was used in IC.Immunoprecipitation Analysis: A 1:50 dilution from a representative lot was used in IP. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysateWesternBlot Analysis: A 1:5,000 dilution of this antibody detected GSK3 alpha in HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P49840 View All» Entrez Gene Number: P49840 View All» Gene Symbol:
  • GSK-3 alpha

  • EC 2.7.11.26

  • DKFZp686D0638

  • OTTHUMP00000198366

  • OTTHUMP00000198367

  • OTTHUMP00000198368

  • EC 2.7.11
    View All» Alternate Names:
    • glycogen synthase kinase 3 alpha

    • glycogen synthase kinase-3 alpha
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation

      • Immunohistochemistry (Paraffin)
        View All» Product Name: Anti-GSK3 alpha, clone EP793Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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