货号：04-338

品牌：Merck Millipore

规格：

目录价：￥3662.00

市场价格：￥3112.70

会员价格：￥2929.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-EGFR Antibody, rabbit | 04-338 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes the C-terminal domain of EGFR and does not cross-react with any other ErbB family member. View All» Molecular Weight: 170 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to the C-terminal region of human EGF Receptor (EGFR). View All» Isotype: IgG View All» Species Reactivity: Human View All» Non-Reactive Species:

• Mouse

• Rat
  View All» Application Notes: Western Blot: 1:10,000 on lysates from A431 cells. Immunoprecipitation: 1:30. Flow Cytometry: 1:10. Permeablization of cells required. Immunofluorescence: 1:50. Paraformaldehyde fixation recommended. Optimal working dilutions must be determined by the end user. View All» Control: POSITIVE: A431 cells. View All» Quality Assurance: Routinely evaluated by immunoblot analysis. View All» Presentation: Rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol. View All» Storage Conditions: 2 years at -20°C from date of shipment. View All» UniProt Number: P00533 View All» Entrez Gene Number:
  • NM_005228.3

  • NM_201282.1

  • NM_201283.1

  • NM_201284.1
    View All» Gene Symbol:
    • EGFR

    • ERBB1

    • ERBB

    • mENA
      View All» Alternate Names: Epidermal growth factor receptor; ERBB; ERBB1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Immunofluorescence

      • Immunoprecipitation

      • Western Blotting
        View All» UniProt Summary: FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.SIZE: 1210 amino acids; 134277 Da SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation." View All» Brand Family: Upstate View All» Product Name: Anti-EGFR Antibody, rabbit | 04-338 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://16ao.com/thread-131720.htm
        © Merck Millipore代理04-338 Anti-EGFR, clone E235 (rabbit monoclonal)，产品报价联系微信jinshanbio