货号：MAB4393

品牌：Merck Millipore

规格：

目录价：￥3662.00

市场价格：￥3112.70

会员价格：￥2929.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Id4 Antibody, clone 10C6.2 | MAB4393 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Immunogen: Recombinant GST Fusion protein (Human Id-4). View All» Clone: 10C6.2 View All» Isotype: IgG2a View All» Background Information: Id-4 is an inhibitor of differentiation protein, which, along with Id1, Id2 and Id3, plays a key role in the regulation of lineage commitment, cell fate decisions and in the timing of differentiation during neurogenesis, lymphopoiesis and neovascularisation (angiogenesis). Id proteins, induced by the bone morphogenic protein-SMAD pathway, have also been shown to collaborate with LIF to ensure that embryonic stem cells opt for self-renewal. View All» Species Reactivity: Human View All» Presentation: Purified ascites. Liquid in PBS, pH 7.0. Contains 0.1% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8C in undiluted aliquots for up to 12 months. View All» UniProt Number: P47928 View All» Entrez Gene Number: NM_001546.2 View All» Gene Symbol: ID4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• ELISA

• Immunocytochemistry
  View All» Entrez Gene Summary: Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995 [PubMed 7665172]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P47928 # ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.SIZE: 161 amino acids; 16622 Da SUBUNIT: Heterodimer with other HLH proteins.SUBCELLULAR LOCATION: Nucleus.SIMILARITY: SwissProt: P47928 ## Contains 1 basic helix-loop-helix (bHLH) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Id4 Antibody, clone 10C6.2 | MAB4393 View All» Concentration: 1mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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