货号：MAB4386

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NDP52 Antibody, clone 10F1.2 | MAB4386 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NDP52. View All» Molecular Weight: ~40 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to mouse NDP52. View All» Clone: 10F1.2 View All» Isotype: IgG1κ View All» Background Information: NDP52, also known as Nuclear Domain 10 protein NDP52 or Calcium-binding and coiled-coil domain-containing protein 2, is a novel protein of the ND10 (nuclear domain 10). It is part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6 and interacts with GEMIN4. NDP52 expression is limited to the pluripotent cells of the early embryo and the germline. It is also expressed in blastocysts, epiblasts and purified primordial germ cells. Recent findings show that NDP52 co-localizes with the ND10 protein PML and can be redistributed upon viral infection and interferon treatment, suggesting that ND10 proteins play an important role in the viral life cycle. Furthermore, NPD252 may play a role in ruffle formation and actin cytoskeleton organization. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Proven to react with mouse. View All» Control: Mouse embryonic stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected NDP52 in 10 µg of mouse embryonic stem cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: A2A6M5 View All» Entrez Gene Number: NP_001093647.1 View All» Gene Symbol:

• NDP52

• CALCOCO2
  View All» Alternate Names:
  • Antigen nuclear dot 52 kDa protein

  • Nuclear domain 10 protein 52

  • Nuclear domain 10 protein NDP52

  • Nuclear dot protein 52

  • calcium binding and coiled-coil domain 2

  • nuclear domain 10 protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion By similarity.SUBUNIT STRUCTURE: Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4 By similarity.SUBCELLULAR LOCATION: Cytoplasm › perinuclear region By similarity. Golgi apparatus By similarity. Cytoplasm › cytoskeleton By similarity. DEVELOPMENTAL STAGE: Expression is limited to the pluripotent cells of the early embryo and the germline. Expressed in blastocysts, epiblasts and purified primordial germ cells. SEQUENCE SIMLARITIES: Belongs to the CALCOCO family.SEQUENCE CAUTION: The sequence BAE38997.1 differs from that shown. Reason: Frameshift at position 193. View All» Product Name: Anti-NDP52, clone 10F1.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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