货号：MAB4371

品牌：Merck Millipore

规格：

目录价：￥4025.00

市场价格：￥3421.25

会员价格：￥3220.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SNAI2 Antibody, clone 2B6 | MAB4371 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This monoclonal antibody recognizes the SNAI2 protein. View All» Molecular Weight: ~30 kDa View All» Immunogen: Synthetic human SNAI2 peptide, a.a. 97-169. View All» Clone: 2B6 View All» Isotype: IgG1κ View All» Background Information: SNAI2 (snail homolog 2) is a neurogenic transcription factor belonging to the SNAIL family and is implicated in both the epithelial-mesenchymal transition and cell survival, as well as in important morphogenetic processes during embryo development and tumor metastasis. Through studies done in chick embryo, this protein has also been identified in the neural crest and in mesodermal cells emigrating from the primitive streak. In addition, SNAI2 has been found to be a key contributor to the function of the stem cell factor/c-kit signaling pathway, and mediates the radioresistance biological function of SCF/c-kit. Consequently, alterations to this gene have been associated to different human syndromes. SNAI2 is predominately expressed in placenta, melanocytes, and differentiating embryonic stem cells, as well as in adult heart, pancreas, liver, kidney, skeletal muscle. View All» Species Reactivity: Human View All» Species Reactivity Note: Reacts with human. Reactivity with other species has not been tested. View All» Quality Assurance: (Based upon representative data from a previous lot).Western Blotting: Recommended working dilution is 1-2 µg/mL. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4) and 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. View All» UniProt Number: O43623 View All» Entrez Gene Number: O43623 View All» Gene Symbol:

• MGC10182

• OTTHUMP00000195093

• SLUG

• SLUGH

• SLUGH1

• WS2D
  View All» Alternate Names:
  • Neural crest transcription factor Slug

  • Protein snail homolog 2

  • slug (chicken homolog), zinc finger protein

  • slug homolog, zinc finger protein

  • slug homolog, zinc finger protein (chicken)

  • snail 2

  • snail homolog 2 (Drosophila)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Transcriptional repressor. Involved in the generation and migration of neural crest cells.SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICITY: Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.INVOLVEMENT IN DISEASE: Defects in SNAI2 are a cause of neural tube defects (NTD). Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. SEQUENCE SIMILARITIES: Belongs to the snail C2H2-type zinc-finger protein family.Contains 5 C2H2-type zinc fingers. View All» Product Name: Anti-SNAI2, clone 2B6 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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