货号：04-278

品牌：Merck Millipore

规格：

目录价：￥3861.00

市场价格：￥3281.85

会员价格：￥3088.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HePTP (PTPN7) Antibody, clone D24 | 04-278 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes HePTP (PTPN7) at ~38-40 kDa. View All» Molecular Weight: 38-40 kDa View All» Immunogen: Full length recombinant His-tag protein. View All» Clone: D24 View All» Isotype: IgG2bκ View All» Species Reactivity: Human View All» Application Notes: Western Blot Analysis: 0.5-2 µg/mL of this lot was used to detect HePTP(PTPN7) in Jurkat cell lysates. View All» Control: Jurkat cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on Jurkat cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing PBS with 0.1% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35236 View All» Entrez Gene Number: NP_002823 View All» Gene Symbol:

• PTPN7

• HePTP

• LPTP

• PTPNI

• BPTP-4

• LC-PTP
  View All» Alternate Names: Protein tyrosine phosphatase, non-receptor type 7 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. SUBUNIT: Monomer. Interacts with MAPK1, MAPK3 and several other MAP kinases. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.TISSUE SPECIFICITY: Expressed exclusively in thymus and spleen. PTM: Phosphorylated on serine residues in resting T-cells. Phosphorylation increases upon exposure to stimuli that increase intracellular cAMP levels. Phosphorylation leads to dissociation of bound MAP kinases. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. SEQUENCE CAUTION: Sequence=AAA59531.1; Type=Frameshift; Positions=5; View All» Product Name: Anti-HePTP (PTPN7), clone D24 Antibody (04-278) View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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