货号：MAB4314

品牌：Merck Millipore

规格：

目录价：￥4502.00

市场价格：￥3826.70

会员价格：￥3601.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD93 Antibody, extracellular, clone R139 | MAB4314 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody recognizes human CD93 (C1qRp), a 90-120kD protein that is highly expressed on monocytes/macrophages, neutrophils and granulocytes. CD93 is not expressed upon T and B lymphocytes. C1qRp binds C1q, the recognition subunit of the first component (C1) of the complement pathway, as well as MBL (Mannose-binding-lectin) and SPA (Pulmonary Surfactant Protein A). However, CD93 is not necessary for the binding of C1q or for inducing C1q-mediated enhancement of phagocytic activity.Recent evidence suggests that CD93 may define a new human stem cell population with hematopoietic and hepatic potential3. View All» Epitope: extracellular View All» Immunogen: C1q collagen like domain binding proteins View All» Clone: R139 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: Immunocytochemistry: Recommended antibody dilution: 5-10 μg/ml Fixative: 4% Paraformaldehyde / PBS Blocking buffer: 2% BSA / 2% Normal serum / PBS Dilution Buffer: 2% BSA / 2% Normal serum / PBS Incubation Times/Temperature: 1 hour at room temperature Recommended control tissue: Positive: U937 monocytes; Negative: T cells Immunoblotting: Recommended primary antibody dilution: 5 μg/ml Dilution buffer: 3% milk powder / 0.05%Tween 20 in Tris buffered saline Sample preparation: Denatured only (SDS & boiled) Preferred Gel percentage: 7.5% Polyacrylamide Blocking Buffer: 3% milk powder / 0.05% Tween 20 in Tris buffered saline Incubation time: 2 hours at room temperature Expected size of band: 97 kDa Recommended control extracts: Positive: U937 monocytes; Negative: T cells Immunoprecipitation: Recommended primary antibody dilution: 5 μg/ml Cell lysis buffer: 10mM TEA, 1mM Calcium Cholride, 0.15M Sodium Chloride, 0.3% NP40 and protease inhibitors Final Reaction volume: 1000 μl Suggested total protein concentration: 0.15 mg/ml (1 x 107 cells) Incubation time: 1 hour at 4°C Expected size of band: 97kDa ELISA (Indirect): Recommended coating concentration: 10 μg/ml Dilution buffer: 0.1M Sodium Carbonate pH9.4 FACS Analysis: Suggested dilution/number of cells: 2 μg/million cells Fixation/Permeabilization used: 1% Paraformaldehyde / PBS Recommended controls: U937 Monocytes Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02 M Phosphate with 0.15 M NaCl, pH 7.6 and 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: Q9NPY3 View All» Entrez Gene Number: NM_012072.3 View All» Gene Symbol:

• CD93

• MXRA4

• C1qRp

• C1qR(P)

• C1qR

• dJ737E23.1

• C1QR1

• CDw93

• p

• C1qRP
  View All» Alternate Names: Complement C1q Receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. View All» Key Applications:
  • Flow Cytometry

  • Immunoprecipitation

  • Western Blotting
    View All» UniProt Summary: FUNCTION: SwissProt: Q9NPY3 # Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.SIZE: 652 amino acids; 68560 Da SUBUNIT: Interacts with HCV core protein.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.PTM: N- and O-glycosylated.SIMILARITY: SwissProt: Q9NPY3 ## Contains 1 C-type lectin domain. & Contains 5 EGF-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-CD93 Antibody, extracellular, clone R139 | MAB4314 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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