货号：04-213

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-c-Jun (Ser73) Antibody, clone E107 | 04-213 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes phosphorylated c-Jun at and around Ser73. View All» Molecular Weight: 48 kDa View All» Epitope: Ser73 View All» Immunogen: KLH conjugated linear peptide corresponding to Phospho c-Jun. View All» Modifications: Phosphorylation View All» Clone: E107 View All» Isotype: IgG View All» Background Information: Jun is a component of the transcription factor AP-1, and can constitute AP-1 activity either as a homodimer or as a heterodimer with Fos. By contrast with Fos, Jun is expressed constitutively, and can be activated by phosphorylation of serines 63 and/or 73. These sites are targets for the SAPK1/JNK family of protein kinases, and their phosphorylation states can be monitored using antibodies specific for the phospho-epitopes. In addition, Jun is phosphorylated by GSK3 on sites which inhibit Jun activity. Since GSK3 is inactivated by Akt, the Akt pathway results in Jun activation. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Proven to react with human and mouse. Not expected to react with rat. View All» Application Notes: Immunohistochemistry: A 1:50 dilution of this antibody clone was was used in IHC.Immunocytochemistry: A 1:100-250 dilution of a previous lot was used in IC. Immunoprecipitation: A 1:80 dilution of a previous lot was used in IP.Flow Cytometry: A 1:20 dilution of a previous lot was used in FC.Dot Blot: A 1:500 dilution of a previous lot was used in DB. View All» Control: NIH/3T3 cell lysate. View All» Quality Assurance: Routinely evaluated by western blot on NIH/3T3 cell lysate.Western Blot Analysis: A 1:1,000 dilution of this lot was used to detect Phospho c-Jun NIH/3T3 cell lysate. View All» Presentation: Unpurified rabbit monoclonal IgG in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P05412 View All» Entrez Gene Number: NP_002219 View All» Gene Symbol:
  • AP-1

  • AP1

  • OTTHUMP00000010036

  • c-Jun

  • p39
    View All» Alternate Names:
    • Activator protein 1

    • Jun activation domain binding protein

    • Proto-oncogene c-jun

    • V-jun avian sarcoma virus 17 oncogene homolog

    • enhancer-binding protein AP1

    • jun oncogene

    • v-jun sarcoma virus 17 oncogene homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Dot Blot

      • Flow Cytometry

      • Immunocytochemistry

      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq] View All» Brand Family: Upstate View All» Product Name: Anti-phospho-c-Jun (Ser73), clone E107 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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