货号：MAB430

品牌：Merck Millipore

规格：

目录价：￥4502.00

市场价格：￥3826.70

会员价格：￥3601.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5) | MAB430 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Detects a human specific cell surface carbohydrate antigen (MW 165-170 kD) on all endothelial and selected epithelial cells. MAB430 reacts with epithelial cells in the breast salivary gland, pancreas and glomerulus. No reaction to epithelial cells in the bowel, skin and proximal tubule. The antigen recognized appears to be the sialoprotein podocalyxin protein View All» Clone: 18.29 (PHM-5) View All» Isotype: IgG1 View All» Background Information: The endothelium is the layer of thin specialized epithelium, comprising a simple squamous layer of cells that line the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall (simple squamous epithelium). Endothelial cells line the entire circulatory system, from the heart to the smallest capillary.Endothelial cells are involved in many aspects of vascular biology, such as vasoconstriction and vasodilation, and hence the control of blood pressure; blood clotting (thrombosis & fibrinolysis); atherosclerosis; formation of new blood vessels (angiogenesis) and inflammation and swelling (oedema). Endothelial cells also control the passage of materials, and the transit of white blood cells, into and out of the bloodstream. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry: 1:20-1:40 (immunoperoxidase). The antigen is stable to heat and trypsin but not neuraminidase digestion. Suitable for use on tissue processed by all routine fixing and embedding techniques. Immunohistochemistry on paraffin embedded tissues: trypsin digestion or HEIR antigen retrieval suggested. Optimal working dilutions must be determined by end user. View All» Control:

• Kidney glomerulus tissue

• HUVEC cells
  View All» Presentation: Liquid in PBS, pH 7.4, with 0.2% BSA and 0.1% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: O00592 View All» Entrez Gene Number:
  • NM_001018111.2

  • NM_005397.3
    View All» Gene Symbol:
    • PODXL

    • MGC138240

    • PCLP

    • podocalyxin-like

    • Gp200

    • PCLP1
      View All» Alternate Names: PCX; Podocalyxin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. View All» UniProt Summary: FUNCTION: SwissProt: O00592 # Functions as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.SIZE: 528 amino acids; 55596 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).TISSUE SPECIFICITY: Glomerular epithelium cell (podocyte).PTM: Glycosylated; contains sialic acid.SIMILARITY: SwissProt: O00592 ## Belongs to the podocalyxin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Epithelium/Endothelial Cells Antibody, clone 18.29 (PHM-5) | MAB430 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µL View All» Target / Localization: Kidney; Surface of select epithelial cells: breast salivary gland, pancreas and glomerulus but all endothelial cells View All» Format: Purified View All» Host: Mouse View All»
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