货号：MAB427

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a View All» Replaces: 06-422 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Dihydropyridine calcium channel, a1 subunit as determined by Western blot (~210 kDa), immunoprecipitation and functional test. Membrane preparations are recommended. The mouse muscle cell line, BC3H1 functions as a good positive control cell line. Reactive with L-type calcium channel alpha1 subunit. Specific for small cell carcinoma and neuroblastoma by FACS analysis. No interaction with squamous cell carcinoma or with cardiac calcium chanel isoforms. View All» Clone: mAB 1a View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rabbit
  View All» Application Notes: Western blot, immunoprecipitation and FACS. Optimal working dilutions must be determined by end user. View All» Presentation: Ascites. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q13698 View All» Entrez Gene Number: NM_000069.2 View All» Gene Symbol:
  • CACNA1S

  • CACH1

  • CCHL1A3

  • hypoPP

  • MHS5

  • CACNL1A3

  • Cav1.1

  • HOKPP

  • CACN1

  • HypoPP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. View All» UniProt Summary: FUNCTION: SwissProt: Q13698 # Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the high-voltage activated (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.SIZE: 1873 amino acids; 212164 Da SUBUNIT: Multisubunit complex consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. An additional gamma subunit is present only in skeletal muscle L-type channel.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Skeletal muscle specific.DOMAIN: SwissProt: Q13698 Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. & The loop between repeats II and III interacts with the ryanodine receptor, and is therefore important for calcium release from the endoplasmic reticulum necessary for muscle contraction.PTM: Phosphorylation by PKA activates the calcium channel (By similarity).DISEASE: SwissProt: Q13698 # Defects in CACNA1S are a cause of hypokalemic periodic paralysis (HYPOKPP) [MIM:170400]; also designated HOKPP. HYPOKPP is an autosomal dominant skeletal muscle disorder manifested by episodic weakness associated with low serum potassium. Muscle weakness could be due to altered excitation-contraction coupling in HYPOKPP patients. & Defects in CACNA1S are the cause of malignant hyperthermia susceptibility 5 (MHS5) [MIM:601887]; an autosomal dominant disorder that is potentially lethal in susceptible individuals on exposure to commonly used inhalational anesthetics and depolarizing muscle relaxants.SIMILARITY: Belongs to the calcium channel alpha-1 subunit family. View All» Brand Family: Chemicon View All» Product Name: Anti-Dihydropyridine-sensitive Calcium Channel α 1 Subunit Antibody, clone 1a View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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