货号：MAB422

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cathepsin D Antibody, clone C5 | MAB422 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Human Cathepsin-D. Fine granular cytoplasmic staining is seen in macrophages and tumor cells reflecting the lysosomal location of the protein. Thus stained cells will often be inconspicuous at low power when only a light staining effect may be seen; medium and high power reveal the lysosomal staining. View All» Immunogen: Cathespin-D purified from human spleen. View All» Clone: C5 View All» Isotype: IgG2b View All» Background Information: Cathepsin D is synthesized as a 54kDa precursor which is proteolytically processed to an intermediate 48kDa single chain which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and connective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types, especially breast cancer. Cathepsin D is expressed in epithelial cells as well as in macrophages. Immunoreactivity of cancer cells and tissue infiltrating macrophages must be recorded separately. View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry Typical working dilution 1:100-1:200 using standard ABC technique, 60 minutes incubation at 25°C. Effective on paraffin-embedded and fresh frozen tissue. Trypsinisation may be required. View All» Control: POSITIVE CONTROL: Many tissues, e.g. most breast carcinomas, have a built-in control in the form of tissue macrophages. Alternatively human liver can be used as a control. View All» Presentation: Liquid tissue culture supernatant containing 15 mM sodium azide. View All» Storage Conditions: Maintain at -20°C in convenient aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P07339 View All» Entrez Gene Number: NM_001909.3 View All» Gene Symbol:

• CTSD

• CLN10

• MGC2311

• CPSD

• EC 3.4.23.5 [Contains: Cathepsin D light chain

• Cathepsin D heavy chain].
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. View All» UniProt Summary: FUNCTION: SwissProt: P07339 # Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.SIZE: 412 amino acids; 44552 Da SUBUNIT: Consists of a light chain and a heavy chain.SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.DISEASE: SwissProt: P07339 # Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127]; also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults, characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes.SIMILARITY: SwissProt: P07339 ## Belongs to the peptidase A1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Cathepsin D Antibody, clone C5 | MAB422 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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