货号：MAB4211

品牌：Merck Millipore

规格：100Ug

目录价：￥3516.00

市场价格：￥2988.60

会员价格：￥2812.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD34 Class I Antibody, clone B1-3C5 | MAB4211 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody belongs to CD34 (assigned by the Third International Workshop on Leukocyte Differentiation Antigens, Oxford, 1987; Hogg & Horton, 1987). It reacts with a 120kD glycoprotein found on progenitor cell populations in human bone marrow and foetal liver (Katz et al., 1985). This antigen is normally restricted to immature human haemopoietic precursor cells (Peschel & Koller, 1989). Cell reactivity (Tindle et al., 1985): Normal: No reaction with normal peripheral lymphocytes, granulocytes, monocytes, erythrocytes and platelets. Reacts with Clinical: Reaction Acute myeloid leukemia (AML, M1 and M2) positive Null lymphoblastic leukemia (Null ALL) positive Common acute lymphoblastic leukemia (CALL) positive Myeloblastic and lymphoblastic crises of chronic granulocytic leukemia (CGL) positive Chronic myeloid leukemia (CML) negative T cell acute lymphoblastic leukemia (TALL) negative B cell acute lymphoblastic leukemia (BALL) negative Chronic lymphocytic leukemia (CLL) negative Cell lines: Reacts with early myeloblast line KG1. No reaction with null, B or T lymphoid, erythroid or later myeloid cell lines. View All» Immunogen: KG1 human acute myelogenous cell line. View All» Clone: B1-3C5 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Identification of CD34 positive cells is important for the diagnosis and classification of acute myeloid leukemia (AML). It is especially useful in patients with poorly differentiated myeloblasts, as well as in myeloblastic crises of chronic granulocytic leukemia. It has been recommended that this antibody be used as part of a panel for screening of leukemia (Batinic et al., 1989). SUGGESTED USAGE DILUTION 1. Flow cytometry and indirect immunofluorescence 1:25 Dilute with isotonic buffer. Use 50 μl of diluted antibody per 1 x 10E6 peripheral blood mononuclear cells (PBMC) or bone marrow cells in 100 μl of buffer. 2. Indirect immunoperoxidase staining - the final dilution will depend on the assay conditions and detection system employed. However, a dilution of at least 1:25 will be applicable to most commonly used systems. View All» Presentation: The antibody is supplied in phosphate buffered saline, pH 7.4, containing 0.2% bovine serum albumin and 0.1% sodium azide. The characteristics of each lot are tested by electrophoresis and flow cytometry. View All» Storage Conditions: For prolonged periods, store below -20°C in undiluted aliquots. AVOID REPEATED FREEZE/THAW CYCLES. Product stable for 6 months when stored as directed. WARNING: The monoclonal reagent solution contains 0.1% sodium azide as a preservative. Due to potential hazards arising from the build up of this material in pipes, spent reagent should be disposed of with liberal volumes of water. View All» UniProt Number: P28906 View All» Entrez Gene Number:

• NM_001025109.1

• NM_001773.2
  View All» Gene Symbol: CD34 View All» Sales Restrictions: This product is not available for sale in the United States. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunofluorescence
    View All» Entrez Gene Summary: CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P28906 # Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.SIZE: 385 amino acids; 40716 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells.PTM: Highly glycosylated. & Phosphorylated on serine residues by PKC.DISEASE:SwissProt: P28906 # Abnormal CD34 expression in leukemogenesis.SIMILARITY: SwissProt: P28906 ## Belongs to the CD34 family. View All» Brand Family: Chemicon View All» Product Name: Anti-CD34 Class I Antibody, clone B1-3C5 | MAB4211 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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