货号：04-1579

品牌：Merck Millipore

规格：

目录价：￥3574.00

市场价格：￥3037.90

会员价格：￥2859.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin-13 (IL-13) Antibody, clone B2 | 04-1579 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~13 kDa observed View All» Epitope: 0 View All» Immunogen: Full-length recombinant protein corresponding to human IL-13. View All» Clone: AB31.56.13G1.B2 View All» Isotype: IgG1κ View All» Background Information: Interleukin-13 (IL-13) is a cytokine that is secreted by helper T cells in reaction to T cell antigen receptor signaling. IL-13 is also secreted by mast cells and basophils when cross-linking with immunoglobulin E. IL-13 seems to play a role as an effector in ulcerative colitis that weakens epithelial barrier function by influencing epithelial apoptosis, tight junctions and restitution velocity. IL-13 has been shown to be involved in the pathogenesis of allergic diseases such as atopic dermatitis. IL-13 seems to also have a role to play in alcohol mediated activation of pro-fibrotic pathways. IL-13 is thought to be an important cytokine during the expansion of asthma and chronic obstructive pulmonary disease and may be critical clinical therapy targets. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX). View All» Control: Human IL-13 recombinant protein View All» Quality Assurance: Evaluated by Western Blot in lysates from cells expressing human IL-13 recombinant protein.Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-13 recombinant protein. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35225 View All» Entrez Gene Number: NP_002179 View All» Gene Symbol:

• NC30

• IL13

• ALRH

• IL-13

• P600

• BHR1, IL13
  View All» Alternate Names:
  • interleukin 13

  • interleukin-13
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.SUBCELLULAR LOCATION: Secreted. INVOLVEMENT IN DISEASE: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator.SEQUENCE CAUTION: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. View All» Product Name: Anti-Interleukin-13 (IL-13), clone B2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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