货号：MAB4140

品牌：Merck Millipore

规格：100Ug

目录价：￥4393.00

市场价格：￥3734.05

会员价格：￥3514.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MDR3 Antibody, clone P3 II-26 | MAB4140 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody reacts with an internal epitope of MDR3 P-gp. It does not cross-react with the human MDR1 P-gp. It has been reported that this clone also cross reacts with mouse MDR2 Pgp {Kok et al 2003 {http://www.biochemj.org/bj/369/0539/3690539.pdf}. View All» Immunogen: Mab was selected after immunization with a fusion protein consisting of Gluthatione-S-Transferase and a fragment of MDR3 P-gp comprising aa 629-692. View All» Clone: P3 II-26 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: Western Blotting: MDR3 is a 140 kDa protein. Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations Immunohistochemistry: 1:20 on acetone-fixed frozen sections Not suitable for paraffin-embedded tissues Optimal working dilutions must be determined by end user. View All» Applications Not Recommended: Immunohistochemistry (Paraffin) View All» Presentation: Liquid containing 0.7% BSA and 0.1% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. View All» UniProt Number: P21439 View All» Entrez Gene Number:

• NM_000443.3

• NM_018849.2

• NM_018850.2
  View All» Gene Symbol:
  • ABCB4

  • PGY3

  • PFIC3

  • PFIC-3

  • MDR2/3

  • MDR3

  • MDR2

  • ABC21

  • GBD1

  • EC 3.6.3.44
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. View All» UniProt Summary: FUNCTION: SwissProt: P21439 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Human MDR3 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.SIZE: 1286 amino acids; 141523 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DISEASE: SwissProt: P21439 # Defects in ABCB4 are the cause of progressive familial intrahepatic cholestasis type III (PFIC3) [MIM:602347]. PFIC3 is an autosomal recessive liver disorder presenting with early onset cholestasis that progresses to cirrhosis and liver failure before adulthood. It is characterized by elevated serum gamma- glutamyltransferase levels. & Defects in ABCB4 are the cause of intrahepatic cholestasis of pregnancy (ICP) [MIM:147480]; also known as obstetric cholestasis. ICP is a liver disorder of pregnancy with serious consequences for the mother and fetus. Cholestasis results from abnormal biliary transport from the liver into the small intestine, and ICP is characterized by the occurrence of cholestasis in pregnancy in women with an otherwise normal medical history. The classical maternal feature is generalized pruritus, becoming more severe with advancing gestation. ICP causes fetal distress, spontaneous premature delivery and unexplained third trimester intrauterine death. & Defects in ABCB4 are a cause of cholelithiasis [MIM:600803]; also known as gallstones.SIMILARITY: SwissProt: P21439 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MDR3 Antibody, clone P3 II-26 | MAB4140 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-131534.htm
      © Merck Millipore代理MAB4140 Anti-MDR3 Antibody, clone P3 II-26;store at -20℃，产品报价联系微信jinshanbio