货号：MAB4120

品牌：Merck Millipore

规格：100Ug

目录价：￥6891.00

市场价格：￥5857.35

会员价格：￥5512.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MDR1 Antibody, clone JSB-1 | MAB4120 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with a conserved cytoplasmic epitope of the plasma membrane-associated 170 kDa P-gp, member of the superfamily of transmembrane transporters. JSB-1 detects P-gp overexpression in human tumor cells of all different histogenetic derivations. JSB-1 does not cross-react with MDR3 P-glycoprotein. JSB-1 has been shown to cross-react with Pyruvate Carboxylase (PC), an abundant Mr 130,000 mitochondrial enzyme, on both immunoblots and immunohistochemical tissue sections [Rao et al. (1995). J Histo. Cytochem. 43(12):1187-1192.] Unequivocal plasma membrane patterns of immunostaining represent true P-glycoprotein ex-presssion. Weak homogeneous, cytoplasmic, or granular patterns of reactivity may represent staining of the PC cross-reactive epitope rather than positive staining for P-glycoprotein. View All» Molecular Weight: 170 kDa View All» Epitope: Cytoplasmic View All» Clone: JSB-1 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Hamster
  View All» Application Notes: Flow Cytometry Immunohistochemistry on frozen and paraffin embedded tissue sections: 1:20. Immunocytochemistry: acetone or air-dried preparations react well. Western blot Note: For cellular detection, permeabilization is required. Optimal working dilutions must be determined by end user. View All» Control: MDR cells View All» Purification Method: Unpurified View All» Presentation: UnPurified mouse culture supernatant containing 0.7% BSA and 0.1% sodium azide as a preservative. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P08183 View All» Entrez Gene Number: NM_000927.3 View All» Gene Symbol:
  • ABCB1

  • PGY1

  • MGC163296

  • GP170

  • ABC20

  • CD243

  • P-gp

  • MDR1

  • CLCS

  • EC 3.6.3.44
    View All» Alternate Names: P-glycoprotein; CD243; p170; Pgp View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» Entrez Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. View All» UniProt Summary: FUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.SIZE: 1280 amino acids; 141463 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MDR1 Antibody, clone JSB-1 | MAB4120 View All» Concentration: Approximately 250 μg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Culture Supernatant View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-131515.htm
      © Merck Millipore代理MAB4120 Anti-MDR1 Antibody, clone JSB-1;store at -20℃，产品报价联系微信jinshanbio