货号：04-1528

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD86 Antibody, clone IT2.2 | 04-1528 View All» Replaces: This antibody is a recommended replacement for CBL520. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CD86. View All» Molecular Weight: ~38 kDa View All» Epitope: Unknown View All» Immunogen: Human LCL whole cells. View All» Clone: IT2.2 View All» Isotype: IgG2bκ View All» Background Information: CD86 (T-lymphocyte activation antigen CD86, activation B7-2 antigen or CTLA-4 counter-receptor B7.2) is a molecule expressed on antigen-presenting cells that provide costimulatory signals necessary for T cell activation and survival. CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Binding of CD86 with CTLA-4 negatively regulates T-cell activation and diminishes the immune response. Along with CD80, CD86 provides stimuli to prime T cells against antigens presented by antigen-presenting cells. CD86 is expressed on a broad spectrum of leukocytes, including B lymphocytes, T lymphocytes, macrophages, dendritic cells, and Langerhans cells, plus astrocytes. CD86 is expressed at low levels by freshly explanted peripheral B and T cells, and its expression is substantially increased by a variety of T and B cell-specific stimuli with a peak expression after 18-42 hours of culture. CD86 has also been shown to be involved in immunoglobulin class switching and triggering of mouse NK cell-mediated cytotoxicity. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Western Blot Analysis: A previous lot was used by an independent laboratory in WB (Esser, M.T., et al., 2001).Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Geissmann, F., et al., 2001). View All» Control: Human PBMC's View All» Quality Assurance: Evaluated by Flow Cytometry in human PBMC's.Flow Cytometry Analysis: A 1:100-125 dilution of this antibody detected CD86 in human PBMC's. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P42081 View All» Entrez Gene Number: NP_008820 View All» Gene Symbol:

• CD86

• B7-2

• B70

• BU63

• CD28LG2

• FUN-1

• LAB72
  View All» Alternate Names:
  • Activation B7-2 antigen

  • B-lymphocyte activation antigen B7-2

  • B7-2 antigen

  • CD28 antigen ligand 2

  • CD86 antigen

  • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)

  • CD86 molecule

  • CTLA-4 counter-receptor B7.2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.SUBUNIT STRUCTURE: Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed by activated B-lymphocytes and monocytes.PTM: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.SEQUENCE SIMILARITIES: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-CD86, clone IT2.2 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Purified View All» Host: Mouse View All»
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