货号：MAB4100

品牌：Merck Millipore

规格：100Ug

目录价：￥3952.00

市场价格：￥3359.20

会员价格：￥3161.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MRP1 Antibody, clone QCRL-1 | MAB4100 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with a defined linear epitope (aa 918-924) of MRP1, a 190 kDa transmembrane phosphoglycoprotein overexpressed in various human multidrug resistant tumor cell lines and tumors (Cole et al., 1992; Hipfner et al., 1994, 1996, 1999; Wright et al, 1998). Does not cross react with the mouse mrp1, or human MDR1, MDR3, MRP2, MRP3, MRP4, MRP5 or MRP6 gene products. View All» Immunogen: Non-denatured membranes prepared from the human small cell lung cancer cell line, H69AR, which highly overexpresses MRP1 (Cole et al., 1992; Hipfner et al., 1994, 1999). View All» Clone: QCRL-1 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Western Blot: 0.2 μg/mL, with HRP-conjugated anti mouse IgG (Hipfner et al., 1994, 1996). Immunocytochemistry: 1:20 - 1:50 on paraformaldehyde-fixed (0.5% in PBS) or 70% methanol-fixed cytospin preparations (Hipfner et al., 1999). Immunohistochemistry on formalin-fixed paraffini-embedded sections following antigen retrieval by microwave heating in citrate (Wright, et al., 1998). Flow cytometry: 1:20 dilution on cells fixed in 0.5% paraformaldehyde in PBS for 30 minutes, followed by anti-mouse FITC (block and wash with solution containing 0.1% Tween) (Hipfner, et al., 1994). Immunoprecipitation (Hipfner, et al., 1994; 1996). Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid in PBS with 0.1% sodium azide. View All» Storage Conditions: Store at 2-8ºC for up to 3 months. For longer term storage, aliquot and freeze at -20ºC. View All» UniProt Number: P33527 View All» Entrez Gene Number:

• NM_019901.1

• NM_019902.1

• NM_004996.3

• NM_019862.2

• NM_019898.2

• NM_019899.2

• NM_019900.2
  View All» Gene Symbol:
  • ABCC1

  • 4transporter)

  • ABC29

  • GS-X

  • ABCC

  • MRP1

  • DKFZp781G125

  • MRP

  • DKFZp686N04233
    View All» Alternate Names: Multidrug Resistance Protein-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. View All» UniProt Summary: FUNCTION: SwissProt: P33527 # May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics (By similarity).SIZE: 1531 amino acids; 171561 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Lung, testis and peripheral blood mononuclear cells.SIMILARITY: SwissProt: P33527 ## Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MRP1 Antibody, clone QCRL-1 | MAB4100 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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