货号：04-1521

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RPA1 p70 Antibody, clone RPA9, 1-30 | 04-1521 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RPA1. View All» Molecular Weight: ~68 kDa View All» Epitope: 0 View All» Immunogen: His-tagged recombinant protein corresponding to human RPA1. View All» Clone: RPA9, 1-30 View All» Isotype: IgG1κ View All» Background Information: Replication protein A (RPA) is a multisubunit complex involved in DNA mismatch repair (MMR) in association with MSH2, MLH1 , PCNA, and DNA polymerase-delta. RPA is a heterotrimer that includes subunits of 70 kDa (RPA1), 32kDa (RPA2), and 14kDa (RPA3). RPA1 p70 kDa is an ssDNA binding protein shown to be phosphorylated by ATM and ATR in response to DNA damage.RPA also functions in the initiation of DNA replication and DNA unwinding at origins of replication. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. View All» Application Notes: Immunocytochemistry Preformed by an external laboratory using representative lot of this antibody. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected RPA1 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P27694 View All» Entrez Gene Number: NM_002945 View All» Gene Symbol:

• RPA1

• REPA1

• RF-A

• RP-A

• RPA70
  View All» Alternate Names:
  • RF-A protein 1

  • RP-A p70

  • Replication factor A protein 1

  • Single-stranded DNA-binding protein

  • replication protein A 70 kDa DNA-binding subunit

  • replication protein A1 (70kD)

  • replication protein A1, 70kDa

  • replication protein A 70 kDa DNA-binding subunit

  • REPA1

  • RPA1

  • HSSB.
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro.SUBUNIT STRUCTURE: Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Belongs to the replication factor A protein 1 family. View All» Product Name: Anti-RPA1 p70, clone RPA9, 1-30 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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