货号：MAB4063

品牌：Merck Millipore

规格：

目录价：￥4902.00

市场价格：￥4166.70

会员价格：￥3921.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-erbB-3, clone SGP.1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: MAB4063 recognizes an extra cellular domain of the c-erb B-3 protein, a 180kDa glycoprotein which is a growth factor receptor with tyrosine kinase activity. c-erb B-3 is expressed widely in normal human tissues, but is overexpressed in some tumors, including those of the breast, stomach, pancreas, and colon. View All» Immunogen: Wheat germ lectin purified c-erb B-3 protein View All» Clone: SGP.1 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Flow Cytometry Immunohistochemistry: frozen tissue sections. Not recomended for use on paraffin embedded tissue sections. ELISA Immunoprecipitation Not recomended for use in Western Blotting. Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended:

• Western Blotting

• Immunohistochemistry (Paraffin)
  View All» Presentation: Liquid, PBS buffer, pH 7.4 containing 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliqouts or -20°C for up to one year. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P21860 View All» Entrez Gene Number:
  • NM_001005915.1

  • NM_001982.2
    View All» Gene Symbol:
    • ERBB3

    • c-erbB-3

    • LCCS2

    • c-erbB3

    • p85-sErbB3

    • p45-sErbB3

    • ErbB-3

    • erbB3-S

    • erbB-3

    • MGC88033

    • HER3

    • p180-ErbB3

    • MDA-BF-1

    • EC 2.7.10.1
      View All» Alternate Names: HER-3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Flow Cytometry

      • Immunohistochemistry

      • Immunoprecipitation
        View All» Entrez Gene Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: SwissProt: P21860 # Binds and is activated by neuregulins and NTAK.SIZE: 1342 amino acids; 148098 Da SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Epithelial tissues and brain.DOMAIN: SwissProt: P21860 The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).DISEASE: SwissProt: P21860 # Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Chemicon View All» Product Name: Anti-c-erbB-3, clone SGP.1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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