货号：MAB4056

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Angiotensin Converting Enzyme Antibody, clone i2H5 | MAB4056 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Angiotensin-converting enzyme [ACE] (N-terminal) View All» Immunogen: Angiotensin-converting enzyme from human lung View All» Clone: i2H5 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry (Danilov et al., 1987; Falkenhahn et al., 1995; Morrell et al., 1995) : 1:1,000 on fresh frozen or 4% paraformaldehyde fixed tissues. Does not work on paraffin embedded tissue. Immunocytochemistry: 1:100. Reacts with endothelial cells, macrophages (activated) and THP1 cells (monocyte line). Immunoprecipitation: 1:1,000 ELISA (Stevens et al., 1990): 1:1,000 Structure-function of ACE (Danilov et al., 1994) Optimal working dilutions must be determined by the end user. View All» Applications Not Recommended: Immunohistochemistry (Paraffin) View All» Presentation: Purified immunoglobulin. Liquid in 100 mM borate buffer, pH 8.0 and 150 mM NaCl. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P22966 View All» Entrez Gene Number:

• NM_152831.1

• NM_000789.2

• NM_152830.1
  View All» Gene Symbol:
  • ACE

  • DCP

  • ACE1

  • carboxycathepsin

  • ACE-T

  • MGC26566

  • DCP1

  • CD143

  • EC 3.4.15.1

  • EC 3.2.1.- [Contains: Angiotensin-converting enzyme, testis- specific isoform, soluble form].

  • EC 3.4.15.1 [Contains: Angiotensin-converting enzyme, somatic isoform, soluble form].
    View All» Alternate Names: ACE; CD143; DCP1; Peptidyl-dipeptidase A; Peptidase P View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P22966 # Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.| P12821 # Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator.COFACTOR: Binds 1 zinc ion per subunit. & Binds 2 chloride ions per subunit.SIZE: 732 amino acids; 83330 Da SUBCELLULAR LOCATION: Angiotensin-converting enzyme, testis- specific isoform, soluble form: Secreted. & Cell membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Spermatocytes, adult testis.DOMAIN: SwissProt: P22966 PTM: Phosphorylated by CK2 on Ser-725; which allows membrane retention (By similarity).DISEASE: SwissProt: P12821 # Genetic variations in ACE may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. & Defects in ACE are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). & Genetic variations in ACE can influence susceptibility to diabetic nephropathy [MIM:603933]. Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.SIMILARITY: SwissProt: P22966 ## Belongs to the peptidase M2 family.| P12821 ## Belongs to the peptidase M2 family.MISCELLANEOUS: The glycosidase activity probably uses different active site residues than the metalloprotease activity. & Inhibitors of ACE are commonly used to treat hypertension and cardiac dysfunction. View All» Brand Family: Chemicon View All» Product Name: Anti-Angiotensin Converting Enzyme Antibody, clone i2H5 | MAB4056 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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