货号：04-1478

品牌：Merck Millipore

规格：EA

目录价：￥3144.00

市场价格：￥2672.40

会员价格：￥2515.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD275/ICOSL Antibody, clone HK5.3 | 04-1478 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CD275/ ICOSL. View All» Molecular Weight: 36 kDa View All» Epitope: Unknown View All» Immunogen: Mouse ICOSL cDNA-transfected NRK cells. View All» Clone: HK5.3 View All» Isotype: IgG2aκ View All» Background Information: Inducible T-cell co-stimulator ligand (ICOS ligand, ICOSL or CD275) is a single-pass type I membrane protein for the T-cell-specific cell surface receptor ICOS, expressed on activated monocytes and dendritic cells. ICOSL/CD275 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and also stimulates B-cell proliferation and differentiation into plasma cells. ICOSL/CD275 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. There are 2 isoforms for ICOSL/CD275. Isoform 1 is widely expressed in tissues whereas isoform 2 is detected only in lymph nodes, leukocytes and the spleen. ICOSL/CD275 expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Control: PMA-stimulated BALB/c splenocytes View All» Quality Assurance: Evaluated by Flow Cytometry in PMA-stimulated BALB/c splenocytes.Flow Cytometry Analysis: 10 µg of this antibody detected CD275/ICOSL in PMA-stimulated BALB/c splenocytes. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9JHJ8 View All» Entrez Gene Number: NP_056605 View All» Gene Symbol:

• ICOSLG

• B7-H2

• B7H2

• B7RP-1

• B7RP1

• CD275

• GL50

• ICOS-L

• ICOSL

• LICOS
  View All» Alternate Names:
  • B7 homolog 2

  • B7-like protein

  • B7-like protein Gl50

  • B7-related protein 1

  • CD275 antigen

  • inducible T-cell co-stimulator ligand

  • transmembrane protein B7-H2 ICOS ligand
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Isoform 1 highest expression in lymphoid tissues, such as spleen (mostly in the marginal zone), lymph nodes (particularly in the cortex and in both primary and secondary follicles), thymus (predominantly in the medulla) and Peyer patches (mostly in the follicles), lower levels in many non-lymphoid tissues, such as brain, heart, kidney, liver, lung, skeletal muscle and testis. Present on freshly isolated splenic B-cells, T-cells, dendritic cells and macrophages. The expression of isoform 2 is restricted to heart, spleen and kidney.DEVELOPMENTAL STAGE: Detected early in hemopoiesis: in the yolk sac at 11.5 and 12.5 dpc and, to a lesser extent, in the liver at 14.5 dpc.SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily. BTN/MOG family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-CD275/ICOSL, clone HK5.3 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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