货号：04-1475

品牌：Merck Millipore

规格：EA

目录价：￥3190.00

市场价格：￥2711.50

会员价格：￥2552.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD27 Antibody, clone RM27-3E5 | 04-1475 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the extracellular domain of CD27. View All» Molecular Weight: ~28 kDa View All» Epitope: Extracellular Domain View All» Immunogen: Recombinant protein corresponding to the extracellular domain of mouse CD27. View All» Clone: RM27-3E5 View All» Background Information: CD27 is a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 and CD30 are also members of the TNF receptor superfamily. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is a membrane bound receptor, but a soluble form of CD27 is also produced. Soluble CD27 is found in body fluids and can be used to monitor local and systemic immune activation. In addition, elevated serum concentrations of soluble CD27 are found in patients with B cell malignancies and soluble CD27 levels strongly correlate with tumor load. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Control: BALB/c splenocytes View All» Quality Assurance: Evaluated by Flow Cytometry in BALB/c splenocytes.Flow Cytometry Analysis: A 1:125 dilution of a biotinylated version of this antibody detected CD27 in BALB/c splenocytes.THIS ANTIBODY IS NOT BIOTINYLATED. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgGκ (mixed) in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P41272 View All» Entrez Gene Number: NP_001028298 View All» Gene Symbol:

• CD27

• S152

• T14

• TNFRSF7

• Tp55
  View All» Alternate Names:
  • CD27 antigen

  • CD27 molecule

  • CD27L receptor

  • T cell activation antigen CD27

  • T cell antivation antigen S152

  • T-cell activation antigen CD27

  • Tumor necrosis factor receptor superfamily member 7

  • tumor necrosis factor receptor superfamily, member 7
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.SUBUNIT STRUCTURE: Homodimer. Interacts with SIVA1 and TRAF2 By similarity.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: In thymus and spleen, but not in non-lymphoid tissues.SEQUENCE SIMILARITIES: Contains 3 TNFR-Cys repeats. View All» Product Name: Anti-CD27, clone RM27-3E5 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Purified View All» Host: Rat View All»
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