货号：04-1468

品牌：Merck Millipore

规格：EA

目录价：￥3144.00

市场价格：￥2672.40

会员价格：￥2515.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PD-1 (CD279) Antibody, clone RMP1-30 | 04-1468 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the extracellular domain of PD-1 (CD279). View All» Molecular Weight: ~ 32 kDa View All» Epitope: Extracellular Domain View All» Immunogen: Recombinant protein corresponding to the extracellular domain of mouse PD-1 (CD279). View All» Clone: RMP1-30 View All» Isotype: IgG2aκ View All» Background Information: Programmed Death 1 (PD-1, PDCD1 or CD279) is a Type I membrane protein and a member of the extended CD28/CTLA-4 family of T cell regulators. The protein's structure includes an extracellular IgV domain followed by a transmembrane region and an intracellular tail. PD-1 is expressed on the surface of activated T cells, B cells, and macrophages, suggesting that compared to CTLA-4, PD-1 more broadly negatively regulates immune responses. PD-1 may also induce cell death, in association with other factors. Mutations in PDCD1 gene are associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2), a chronic inflammatory disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. This disease, which is due to PD-1 disfunction, is thought to represent a failure of the regulatory mechanisms of the autoimmune system. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Control: PMA-stimulated BALB/c splenocytes View All» Quality Assurance: Evaluated by Flow Cytometry in PMA-stimulated BALB/c splenocytes.Flow Cytometry Analysis: 10 µg of this antibody detected PD-1 (CD279) in PMA-stimulated BALB/c splenocytes. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q02242 View All» Entrez Gene Number: NP_032824 View All» Gene Symbol:

• PDCD1

• CD279

• PD1

• SLEB2

• hPD-1

• hPD-l
  View All» Alternate Names:
  • CD279 antigen

  • Protein PD-1

  • programmed cell death 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: Possible cell death inducer, in association with other factors.SUBUNIT STRUCTURE: Monomer.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Thymus.DEVELOPMENTAL STAGE: Induced at programmed cell death.SEQUENCE SIMILARITIES: Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-PD-1 (CD279), clone RMP1-30 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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