货号：04-1461

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD80 (B7-1) Antibody, clone RM80 | 04-1461 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CD80 (B7-1). View All» Molecular Weight: ~35 kDa View All» Epitope: Unknown View All» Immunogen: Mouse CD80 cDNA-transfected P815 cells. View All» Clone: RM80 View All» Isotype: IgG2aκ View All» Background Information: T-lymphocyte activation antigen CD80 (Activation B7-1 antigen or CTLA-4 counter-receptor B7.1) is found on activated B cells and monocytes, and is involved in costimulatory signals necessary for T cell activation and survival. CD80 mainly binds to CD28, and along with CD86, provides the necessary stimuli to prepare T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Reactive oxygen stimulates dendritic cells to activate other immune cells, resulting in the up-regulated production of CD80. Activation of this pathway leads to increased T cell TNF production. CD80 is expressed on activated B-cells, macrophages and dendritic cells and also interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC (Ogawa, S., et al., 2001). View All» Control: RAW264.7 cells View All» Quality Assurance: Evaluated by Flow Cytometry in RAW264.7 cells.Flow Cytometry Analysis: 5 µg of this antibody detected CD80 (B7-1) in RAW264.7 cells. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q00609 View All» Entrez Gene Number: NP_033985 View All» Gene Symbol:

• CD80

• B7

• BB1

• CD28LG

• CD28LG1

• LAB7
  View All» Alternate Names:
  • Activation B7-1 antigen

  • B-lymphocyte activation antigen B7

  • CD80 antigen

  • CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)

  • CD80 molecule

  • CTLA-4 counter-receptor B7.1

  • costimulatory factor CD80

  • costimulatory molecule variant IgV-CD80
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Expressed on activated B-cells, gamma interferon stimulated monocytes and non-circulating B-cell malignancies.DEVELOPMENTAL STAGE: Expressed between 4 and 12 hours post-activation. Protein was detected at cell surface at 24 hours and it's expression was maximal from 48 to 72 hours post-activation.SEQUENCE SIMILARITIES: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-CD80 (B7-1), clone RM80 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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