货号：MAB390-100UG

品牌：Merck Millipore

规格：100Ug

目录价：￥29008.00

市场价格：￥24656.80

会员价格：￥23206.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Trade Name: Chemicon (Millipore) View All» Specificity: Rat NGF receptor. MAB365 is the monoclonal antibody used for MAB390-SAP View All» Clone: 192 View All» Isotype: IgG1 View All» Species Reactivity: Rat View All» Non-Reactive Species:

• Human

• Mouse
  View All» Application Notes: Immunotoxin (see "Protocols" for Technical Notes) View All» Presentation: Saporin Conjugated. 192-IgG-SAP is sterile filtered and presented in Dulbecco's PBS with no preservative. View All» Storage Conditions: Centrifuge material at low speed in microfuge to ensure all of the solution is at the bottom of the tube. Vortex gently. Long term storage at -70ºC or below. Short term storage at -20ºC or 2-8ºC with appropriate antibacterial agent if compatible with the intended application. The sterile conjugate is stable at 2-8ºC for several months. Avoid repeated freezing and thawing. Glycerol (1:1) can be added for additional stability if compatible with the intended application. This immunotoxin may be handled safely using standard laboratory procedures as the cross-species reactivity between these anti-rat p75 antibodies and the human form of p75 is negligible. View All» UniProt Number: P08138 View All» Entrez Gene Number: NM_002507.2 View All» Gene Symbol:
  • NGFR

  • p75(NTR)

  • TNFRSF16

  • Gp80-LNGFR

  • CD271
    View All» Alternate Names: p75 Low Affinity Neurotrophin Receptor; NGFR View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. View All» UniProt Summary: FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.SIZE: 427 amino acids; 45183 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9.PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues.SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-p75 Low Affinity Nerve Growth Factor Receptor Antibody, Saporin conjugated, clone 192 View All» Concentration: 1.14 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Saporin View All» Host: Mouse View All»
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