货号：04-1156

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PDGF Receptor β (Tyr740) Antibody, clone EP2135Y, Rabbit | 04-1156 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects PDGF-Receptor β phosphorylated at Tyr740. View All» Molecular Weight: ~190 kDa View All» Epitope: Phosphorylated Tyr740 View All» Immunogen: Phospho-specific peptide corresponding to residues surrounding Tyr740 of human PDGF-Receptor β. View All» Modifications: Phosphorylation View All» Clone: EP2136Y View All» Isotype: IgG View All» Background Information: PDGF, which is a human platelet derived growth hormone, is a tyrosine kinase receptor. PDGF is involved in cell proliferation, migration, and survival. There are two isoforms of PDGF, PDGF receptor-α and PDGF receptor-β. PDGF receptor-β can only bind two specific PDGF isoforms, PDGF-β and PDGF-Δ. Tyr751 and Tyr740 are required for PDGFR-β mediated PI3 kinase activation. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Mouse View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot on NIH/3T3 cell lysates.Western Blot Analysis: A 1:1,000-2,000 dilution of this antibody was used to detect PDGF Receptor β in NIH/3T3 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P01127 View All» Entrez Gene Number: NP_002600.1 View All» Gene Symbol:

• Becaplermin

• FLJ12858

• PDGF-2

• PDGF2

• SIS

• SSV

• becaplermin

• c-sis
  View All» Alternate Names:
  • PDGF subunit B

  • PDGF, B chain

  • Platelet-derived growth factor B chain

  • Platelet-derived growth factor beta polypeptide

  • Platelet-derived growth factor, beta polypeptide (oncogene SIS)

  • platelet-derived growth factor 2

  • platelet-derived growth factor beta

  • platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

  • platelet-derived growth factor, B chain
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. View All» UniProt Summary: FUNCTION: Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.SUBUNIT STRUCTURE: Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with XLKD1 By similarity. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. INVOLVEMENT IN DISEASE: A chromosomal aberration involving PDGFB is a cause of dermatofibrosarcoma protuberans (DFSP) [MIM:607907]. Translocation t(17;22)(q22;q13) with COLA1. DFSP is an uncommon, locally aggressive, but rarely metastasizing tumor of the deep dermis and subcutaneous tissue. It typically occurs during early or middle adult life and is most frequently located on the trunk and proximal extremities. Pharmaceutical use Available under the name Regranex (Ortho-McNeil). Used to promote healing in diabetic neuropathic foot ulcers.MISCELLANEOUS: A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.SEQUENCE SIMILARITIES: Belongs to the PDGF/VEGF growth factor family. View All» Product Name: Anti-phospho-PDGF Receptor β (Tyr740), clone EP2135Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-131411.htm
      © Merck Millipore代理04-1156 Anti-phospho-PDGF Receptor ß (Tyr740), clone EP2135Y, Rabbit Monoclonal，产品报价联系微信jinshanbio