货号：04-1133

品牌：Merck Millipore

规格：

目录价：￥4376.00

市场价格：￥3719.60

会员价格：￥3500.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TIMP-1 Antibody, clone EP1549RY, Rabbit | 04-1133 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes TIMP-1. View All» Molecular Weight: ~ 28-30 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to residues in the C-terminal region of human TIMP-1. View All» Clone: EP1549RY View All» Isotype: IgG View All» Background Information: Tissue Inhibitors of Metalloproteinases (TIMPs) inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-1 and TIMP-2 have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72 kDa type IV collagenase (also known as MMP-2), and latent and active forms 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-1 levels in quiescent cells and tissues are low (pg/ml), and stimulation with the phorbol ester TPA or protein concentration is often needed to visualize protein bands. In addition, cell types differ greatly in the amount of TIMP-1 produced. View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Control: Recombinant protein View All» Quality Assurance: Evaluated by Western Blot.Western Blot Analysis: 1:100-500 dilution of this antibody was used to detect TIMP-1. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P01033 View All» Entrez Gene Number: P01033 View All» Gene Symbol:

• CLGI

• EPA

• EPO

• FLJ90373

• HCI

• OTTHUMP00000023214

• TIMP

• TIMP-1
  View All» Alternate Names:
  • Collagenase inhibitor

  • Erythroid-potentiating activity

  • Fibroblast collagenase inhibitor

  • TIMP metallopeptidase inhibitor 1

  • Tissue inhibitor of metalloproteinases

  • erythroid potentiating activity

  • tissue inhibitor of metalloproteinase 1

  • tissue inhibitor of metalloproteinase 1 (erythroidpotentiating activity, collagenase inhibitor)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.SUBCELLULAR LOCATION: Secreted. PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.SEQUENCE SIMILARITIES: Belongs to the protease inhibitor I35 (TIMP) family. [View classification]Contains 1 NTR domain. View All» Product Name: Anti-TIMP-1, clone EP1549RY, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-131368.htm
    © Merck Millipore代理04-1133 Anti-TIMP-1, clone EP1549RY, Rabbit Monoclonal，产品报价联系微信jinshanbio