货号：04-1130

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LEF-1/TCF-1 α Antibody, clone EP2030Y, Rabbit | 04-1130 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LEF-1/TCF-1 α. Recognition mpas to an epitope in amino acids 236-242 of LEF-1. This region is found within the transactivation domain of LEF-1. However, it is not present in some splice variants. View All» Molecular Weight: ~55 kDa View All» Immunogen: Synthetic peptide corresponding to human LEF-1/TCF-1 α. View All» Clone: EP2030Y View All» Isotype: IgG View All» Background Information: Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate, and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 236-242 of LEF-1. This region is found within the transactivation domain of LEF-1. However, it is not present in some splice variants. View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Application Notes: Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LEF-1/TCF-1 α in human colon adenocarcinoma tissue.Immunocytochemistry Analysis: A 1:100-250 dilution from a representative lot was used in IC.Flow Cytometry: A 1:20 dilution of a representative lot was used in flow cytometry. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot on Jurkat cell lysates.Western Blot Analysis: A 1:25,000-50,000 dilution of this antibody was used to detect LEF-1/TCF-1 α in Jurkat cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q9UJU2 View All» Entrez Gene Number: NM_016269.2 View All» Gene Symbol:

• LEF-1

• TCF1ALPHA

• TCF1-alpha
  View All» Alternate Names:
  • lymphoid enhancer-binding factor 1

  • T cell-specific transcription factor 1-alpha
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry

    • Flow Cytometry
      View All» Product Name: Anti-LEF-1/TCF-1 α, clone EP2030Y, Rabbit Monoclonal Antibody (04-1130) View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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