货号：MAB3783

品牌：Merck Millipore

规格：

目录价：￥3440.00

市场价格：￥2924.00

会员价格：￥2752.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cullin 1 Antibody, clone AS97.1 | MAB3783 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human and mouse Cullin-1. View All» Immunogen: Recombinant human Cullin-1 View All» Clone: AS97.1 View All» Isotype: IgG2a View All» Background Information: Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Western blot Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. View All» UniProt Number: Q13616 View All» Entrez Gene Number: NM_003592.2 View All» Gene Symbol:
  • CUL1

  • MGC149835

  • CUL-1

  • MGC149834

  • Cullin-1
    View All» Alternate Names: CUL-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q13616 # Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.SIZE: 776 amino acids; 89679 Da SUBUNIT: Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2, where it interacts directly with SKP1, SKP2 and RBX1. Interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with COPS2.TISSUE SPECIFICITY: Expressed in lung fibroblasts.PTM: Neddylated; which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.SIMILARITY: SwissProt: Q13616 ## Belongs to the cullin family. View All» Brand Family: Chemicon View All» Product Name: Anti-Cullin 1 Antibody, clone AS97.1 | MAB3783 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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