货号：04-1113

品牌：Merck Millipore

规格：

目录价：￥4258.00

市场价格：￥3619.30

会员价格：￥3406.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FADD (N-terminal) Antibody, clone EP887Y, Rabbit | 04-1113 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FADD. View All» Molecular Weight: ~28 kDa View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human FADD. View All» Clone: EP887Y View All» Isotype: IgG View All» Background Information: FADD was originally isolated as a protein that bound to the cytoplasmic domain of Fas in the yeast two-hybrid system. Sequence analysis revealed a region homologous to the death domain of Fas and TNFR-1. Subsequent biochemical studies have shown that FADD associates with FAS through interaction of the death domains. When over expressed in several cell lines, FADD induces apoptosis, which can be blocked by CrmA, an inhibitor of inerleukin-1-beta-converting enzyme. This evidence suggests that FADD plays a role in Fas-mediated apoptosis. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse View All» Application Notes: Immunohistochemistry Analysis: 1:250 dilution from a previous lot detected FADD in human lung tissue. View All» Control: Jurkat lysates View All» Quality Assurance: Evaluated by Western Blot on Jurkat cell lysates.Western Blotting Analysis: 1:500 dilution of this antibody was used to detect FADD in Jurkat cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl containing 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q13158 View All» Entrez Gene Number: NP_034305.1 View All» Gene Symbol:
  • GIG3

  • MGC8528

  • MORT1
    View All» Alternate Names:
    • FAS-associated death domain protein

    • FAS-associating death domain-containing protein

    • Fas (TNFRSF6)-associated via death domain

    • Fas-associated via death domain

    • Fas-associating protein with death domain

    • Mediator of receptor induced toxicity

    • growth-inhibiting gene 3 protein

    • mediator of receptor-induced toxicity
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» UniProt Summary: FUNCTION: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.SUBUNIT STRUCTURE: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD.TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.DOMAIN: Contains a death domain involved in the binding of the corresponding domain within Fas receptor.PTM: Phosphorylated. SEQUENCE SIMILARITY: Contains 1 death domain.Contains 1 DED (death effector) domain. View All» Product Name: Anti-FADD (N-term.), clone EP887Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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