货号：04-1108

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vitronectin Antibody, clone EP873Y, Rabbit | 04-1108 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Vitronectin. View All» Molecular Weight: ~ 75 kDa View All» Immunogen: Synthetic peptide corresponding to residues near the V10 subunit of human vitronectin. View All» Clone: EP873Y View All» Isotype: IgG View All» Background Information: Vitronectin (Serum Spreading Factor, Complement S-Protein) is a plasma protein and a component of the extracellular matrix in many tissues, where it promotes cell adhesion and spreading. Vitronectin also inhibits complement C5b-9-mediated cytolysis and regulates the action of thrombin. Vitronectin contains the cell binding sequence arg gly asp (RGD) and serves as a cell-to-substrate adhesion molecule, (Stefansson, 1996). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: 1:100-250 dilution from a previous lot detected Vitronectin in human liver tissue.Immunocytochemistry: 1:50-100 dilution from a previous lot was used in IC. View All» Control: Human serum membrane lysates View All» Quality Assurance: Evaluated by Western Blot on human serum membrane lysate.Western Blot Analysis: 1:20,000 dilution of this antibody was used to detect Vitronectin in human serum membrane lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P04004 View All» Entrez Gene Number: P04004 View All» Gene Symbol:
  • S-protein

  • V75

  • VN

  • VNT

  • epibolin

  • vitronectin
    View All» Alternate Names:
    • Serum-spreading factor

    • complement S-protein

    • serum spreading factor

    • somatomedin B

    • vitronectin (serum spreading factor, somatomedin B,complement S-protein)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.SUBUNIT STRUCTURE: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin. SUBCELLULAR LOCATION: Secreted › extracellular space. TISSUE SPECIFICITY: Plasma.DOMAIN: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.PTM: Sulfated on 2 tyrosine residues.N- and O-glycosylated By similarity.Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.SEQUENCE SIMILARITIES: Contains 4 hemopexin-like domains.Contains 1 SMB (somatomedin-B) domain. View All» Product Name: Anti-Vitronectin, clone EP873Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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