货号：MAB3738

品牌：Merck Millipore

规格：100UL

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PML Antibody, clone 36.1-104 | MAB3738 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes mouse PML (Promyelocytic Leukemia protein). On western blots of protein extracts from mouse embryo fibroblast (MEF1 cells), MAB3738 recognizes a band migrating at approximately 106 kDa corresponding to PML. View All» Molecular Weight: 106 kDa View All» Immunogen: His-tagged PML fusion protein corresponding to amino acids 1-581 of mouse PML. View All» Clone: 36.1-104 View All» Isotype: IgG2b View All» Background Information: PML protein is a tripartite motif (TRIM)-containing nuclear protein that may function as, among other things, a transcription factor, a coactivator of nuclear receptors (Ruggerio, 2000), a regulator of apoptosis (Guo, 2000), a mediator of interferon-induced antiviral response (Regand and Chelbi-Aliz, 2001), and as a suppressor of growth and oncogenic transformation (Mu, 1997). PML is localized to the nucleoplasm and in distinct subnuclear structures referred to as Promyelocytic Leukemia Bodies (also known as Nuclear Domain 10). Localization of PML to Promyelocytic Leukemia Bodies requires modification of PML protein by the Small Ubiquitin Modifier (SUMO) and is required for proper formation and integrity of these subnuclear structures. At least 14 splice variants of PML ranging in molecular weight from 48-97 kDa (predicted) have been described in the literature. The functional significance of the various splice variants is not well understood. In patients with Acute Promyelocytic Leukemia, the PML gene is involved in at least two specific chromosomal translocations that result in the expression of chimeric proteins with the Retinoic Acid Receptor alpha (RARalpha DNA- and Hormone-binding domains; Pandolfi, 2001). All isoforms of PML, as well as the PML-RARalpha chimeric proteins expressed in Type A and Type B APL contain an identical N-terminus but vary in the C-terminal portion of the protein (Jenson, 2001). View All» Species Reactivity: Mouse View All» Non-Reactive Species: Human View All» Application Notes: Western blot (1:500) Immunoprecipitation Immunocytochemistry (1:100) Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: Mouse embryo fibroblasts (MEF1 cells). View All» Purification Method: Unpurified View All» Presentation: Ascites fluid containing no preservatives. View All» Storage Conditions: Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P29590 View All» Entrez Gene Number:

• NM_002675.3

• NM_033238.2

• NM_033239.2

• NM_033240.2

• NM_033244.3

• NM_033246.2

• NM_033247.2

• NM_033249.2

• NM_033250.2
  View All» Gene Symbol:
  • PML

  • PP8675

  • RNF71

  • TRIM19

  • MYL
    View All» Alternate Names: Promyelocytic Leukemia Protein; Tripartite Motif Protein 19 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. View All» UniProt Summary: FUNCTION: SwissProt: P29590 # Probable transcription factor. May play an important role in recruitment of ELF4 into PML nuclear bodies.SIZE: 882 amino acids; 97517 Da SUBUNIT: Interacts with SIRT1, TOPBP1, TRIM27 and TRIM69. Interacts with the C-terminus of ELF4. Interacts with Lassa virus Z protein and rabies virus phosphoprotein (By similarity).SUBCELLULAR LOCATION: Nucleus. Note=Localized to PML nuclear bodies.PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.DISEASE: SwissProt: P29590 # A chromosomal aberration involving PML may be a cause of acute promyelocytic leukemia (APL). Translocation t(15;17)(q21;q21) with RARA. The PML breakpoints (type A and type B) lie on either side of an alternatively spliced exon.SIMILARITY: SwissProt: P29590 ## Contains 2 B box-type zinc fingers. & Contains 1 RING-type zinc finger. View All» Brand Family: Chemicon View All» Product Name: Anti-PML Antibody, clone 36.1-104 | MAB3738 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Ascites View All» Host: Mouse View All»
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