货号：MAB3706

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 | MAB3706 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes the cytoplasmic tail of CD4. Many functions have been assigned to this tail, including anti-viral regulation (down/up regulation of CD4), T-cell maturation, activation and differentiation, and Lck signal transduction, among others. This antibody is useful as a control for studies involving targeting of intracellular protein domains of T cells. View All» Epitope: intracellular View All» Immunogen: Synthetic peptide corresponding to amino acids 439-458 of the cytoplasmic tail of human CD4. View All» Clone: 024-10D6.B3 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Immunocytochemistry ELISA Stimulation/Inhibition of biological activity Electrophoretic mobility shift analysis Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02 M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months from date of receipt. View All» UniProt Number: P01730 View All» Entrez Gene Number: NM_000616.3 View All» Gene Symbol:

• CD4

• CD4mut
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Electrophoretic Mobility Shift Assay

  • Affects Function

  • Immunocytochemistry
    View All» UniProt Summary: FUNCTION: SwissProt: P01730 # Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.SIZE: 458 amino acids; 51111 Da SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.SIMILARITY: SwissProt: P01730 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.MISCELLANEOUS: Primary receptor for HIV-1." View All» Brand Family: Chemicon View All» Product Name: Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 | MAB3706 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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