货号：04-1079

品牌：Merck Millipore

规格：

目录价：￥3416.00

市场价格：￥2903.60

会员价格：￥2732.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcium/Calmodulin Kinase II Antibody, clone EP1829Y, Rabbit | 04-1079 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Calcium/Calmodulin Kinase II. View All» Molecular Weight: ~45-70 kDa (2 isoforms) View All» Immunogen: Synthetic peptide corresponding to residues on human Calcium/Calmodulin Kinase II. View All» Clone: EP1829Y View All» Isotype: IgG View All» Background Information: The Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV, Phosphorylase Kinase, and MLCK. The CaM Kinases are inactive in the absence of stimuli; binding to Ca2+/Calmodulin induces conformational changes and activation. CaM Kinases have broad substrate specificity, with many cellular functions. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:100-250 dilution from a previous lot detected Calcium/Calmodulin Kinase II in human brain carcinoma tissue.Immunocytochemistry Analysis: A 1:250-500 dilution from a previous lot was used in IC.Flow Cytometry: A 1:80 dilution of a previous lot was used in flow cytometry.Immunoprecipitation Analysis: A 1:50 dilution from a previous lot was used in IP.Immunohistochemistry (Paraffin) Analysis:Representative lot data.Immunohistochemical staining of paraffin-embedded human brain carcinoma using Anti-Calcium/Calmodulin Kinase II, clone EP1829Y. View All» Control: Mouse brain lysate View All» Quality Assurance: Evaluated by Western Blot on Mouse brain lysates.Western Blot Analysis: A 1:20,000 dilution of this antibody was used to detect Calcium/Calmodulin Kinase II in mouse brain lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q96RR4 View All» Entrez Gene Number: NM_015981.2 View All» Gene Symbol:
  • CAMKK

  • CAMKKB

  • EC 2.7.11.17

  • KIAA0787

  • MGC15254
    View All» Alternate Names:
    • CAMKK beta protein

    • CaM-KK beta

    • CaM-kinase kinase beta

    • CaMKK beta

    • Calcium/calmodulin-dependent protein kinase kinase beta

    • calcium/calmodulin-dependent protein kinase beta

    • calcium/calmodulin-dependent protein kinase kinase 2 beta

    • calcium/calmodulin-dependent protein kinase kinase 2, beta
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Immunoprecipitation

      • Flow Cytometry
        View All» UniProt Summary: FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal activation of CREB1 By similarity.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.ENZYME REGULATION: Activated by Ca2+/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca2+/calmodulin. In part, activity is independent on Ca2+/calmodulin By similarity.SUBUNIT STRUCTURE: Interacts with calmodulin By similarity.SUBCELLULAR LOCATION:Cytoplasm By similarity. TISSUE SPECIFICITY: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. DOMAIN: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates By similarity.PTM: Autophosphorylated By similarity.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain. View All» Product Name: Anti-Calcium/Calmodulin Kinase II, clone EP1829Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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